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MFSD4B major facilitator superfamily domain containing 4B [ Homo sapiens (human) ]

Gene ID: 91749, updated on 3-May-2025
Official Symbol
MFSD4Bprovided by HGNC
Official Full Name
major facilitator superfamily domain containing 4Bprovided by HGNC
Primary source
HGNC:HGNC:21053
See related
Ensembl:ENSG00000173214 MIM:617331; AllianceGenome:HGNC:21053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NaGLT1; SLC60A2; KIAA1919
Summary
Predicted to enable symporter activity. Predicted to be involved in sodium ion transport and transmembrane transport. Predicted to be located in apical plasma membrane. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in placenta (RPKM 2.0), testis (RPKM 1.6) and 24 other tissues See more
Orthologs
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See MFSD4B in Genome Data Viewer
Location:
6q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (111259339..111280005)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (112442435..112463097)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111580542..111601208)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 10 Neighboring gene uncharacterized LOC124901377 Neighboring gene MFSD4B divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr6:111573581-111573781 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111575060-111575706 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111575707-111576354 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111576355-111577001 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111577002-111577648 Neighboring gene uncharacterized LOC124901378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24942 Neighboring gene Sharpr-MPRA regulatory region 12211 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_87657 Neighboring gene uncharacterized LOC124901376 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:111604271-111604834 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:111604835-111605396 Neighboring gene REV3 like, DNA directed polymerase zeta catalytic subunit Neighboring gene FCF1 pseudogene 5

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC33953

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
sodium-dependent glucose transporter 1
Names
major facilitator superfamily domain-containing protein 4B

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153369.4NP_699200.2  sodium-dependent glucose transporter 1

    See identical proteins and their annotated locations for NP_699200.2

    Status: VALIDATED

    Source sequence(s)
    AB067506, AI096577, AI151460, AK093136, AL080317, BC036115, BG697347, DB024559, DB027926, DB202540
    Consensus CDS
    CCDS5090.1
    UniProtKB/Swiss-Prot
    A8K9M0, Q5TF39, Q8IYB6, Q96PW9, Q9P0D6
    UniProtKB/TrEMBL
    B3KSA1
    Related
    ENSP00000500934.1, ENST00000671876.2
    Conserved Domains (2) summary
    cd06174
    Location:1405
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:2370
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    111259339..111280005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    112442435..112463097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)