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MFSD4B major facilitator superfamily domain containing 4B [ Homo sapiens (human) ]

Gene ID: 91749, updated on 27-Jun-2020

Summary

Official Symbol
MFSD4Bprovided by HGNC
Official Full Name
major facilitator superfamily domain containing 4Bprovided by HGNC
Primary source
HGNC:HGNC:21053
See related
Ensembl:ENSG00000173214 MIM:617331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NaGLT1; KIAA1919
Expression
Ubiquitous expression in placenta (RPKM 2.0), testis (RPKM 1.6) and 24 other tissues See more
Orthologs

Genomic context

See MFSD4B in Genome Data Viewer
Location:
6q21
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (111259279..111280005)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111580482..111590263)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 10 Neighboring gene small nucleolar RNA, C/D box 166 Neighboring gene uncharacterized LOC107986521 Neighboring gene REV3 like, DNA directed polymerase zeta catalytic subunit Neighboring gene FCF1 pseudogene 5 Neighboring gene bromodomain containing 7 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33953

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium-dependent glucose transporter 1
Names
major facilitator superfamily domain-containing protein 4B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153369.4NP_699200.2  sodium-dependent glucose transporter 1

    See identical proteins and their annotated locations for NP_699200.2

    Status: VALIDATED

    Source sequence(s)
    AB067506, AI096577, AI151460, AK093136, AL080317, BC036115, BG697347, DB024559, DB027926, DB202540
    Consensus CDS
    CCDS5090.1
    UniProtKB/Swiss-Prot
    Q5TF39
    UniProtKB/TrEMBL
    B3KSA1
    Related
    ENSP00000500934.1, ENST00000671876.2
    Conserved Domains (2) summary
    cd06174
    Location:1405
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:2370
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    111259279..111280005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011483.1XP_016866972.1  sodium-dependent glucose transporter 1 isoform X1

    Related
    ENSP00000500014.1, ENST00000673024.1

RNA

  1. XR_001743740.2 RNA Sequence

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