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ACY3 aminoacylase 3 [ Homo sapiens (human) ]

Gene ID: 91703, updated on 23-Nov-2021

Summary

Official Symbol
ACY3provided by HGNC
Official Full Name
aminoacylase 3provided by HGNC
Primary source
HGNC:HGNC:24104
See related
Ensembl:ENSG00000132744 MIM:614413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACY-3; HCBP1
Expression
Biased expression in kidney (RPKM 28.0), duodenum (RPKM 26.6) and 8 other tissues See more
Orthologs
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Genomic context

See ACY3 in Genome Data Viewer
Location:
11q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67642551..67650829, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67410026..67418201, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 8 Neighboring gene T-box transcription factor 10 Neighboring gene aldehyde dehydrogenase 3 family member B2 Neighboring gene ribosomal protein L37 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genetic determinants influencing human serum metabolome among African Americans.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9740

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aminoacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aminoacylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
Names
HCV core-binding protein 1
acylase III
aspartoacylase (aminoacylase) 3
aspartoacylase (aminocyclase) 3
aspartoacylase-2
hepatitis C virus core-binding protein 1
NP_542389.1
XP_016874038.1
XP_016874039.1
XP_016874040.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080658.2NP_542389.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

    See identical proteins and their annotated locations for NP_542389.1

    Status: VALIDATED

    Source sequence(s)
    AP003385, BC008689
    Consensus CDS
    CCDS8175.1
    UniProtKB/Swiss-Prot
    Q96HD9
    UniProtKB/TrEMBL
    A0A024R5L2
    Related
    ENSP00000255082.3, ENST00000255082.8
    Conserved Domains (1) summary
    cd06909
    Location:12300
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    67642551..67650829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018549.1XP_016874038.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

  2. XM_017018550.1XP_016874039.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

  3. XM_017018551.1XP_016874040.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X2

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