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CD3G CD3g molecule [ Homo sapiens (human) ]

Gene ID: 917, updated on 8-Jul-2021

Summary

Official Symbol
CD3Gprovided by HGNC
Official Full Name
CD3g moleculeprovided by HGNC
Primary source
HGNC:HGNC:1675
See related
Ensembl:ENSG00000160654 MIM:186740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T3G; IMD17; CD3-GAMMA
Summary
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 14.5), appendix (RPKM 7.1) and 9 other tissues See more
Orthologs
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Genomic context

See CD3G in Genome Data Viewer
Location:
11q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (118344344..118355161)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118215059..118225876)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD3e molecule Neighboring gene CD3d molecule Neighboring gene ubiquitination factor E4A Neighboring gene uncharacterized LOC100131626 Neighboring gene ATP synthase membrane subunit g

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits CD3-induced Lck activation and cellular tyrosine phosphorylation, particularly of phosphoinositide-specific phospholipase C-gamma-1 PubMed
env Binding of HIV-1 gp120 to the CD4 receptor molecule results in co-stimulation of CD3-induced T cell activation PubMed
env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed
env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
Envelope transmembrane glycoprotein gp41 env Gp41 TMD co-localizes with the CD3-TCR complex and inhibits T-cell activation induced by antibodies to CD3 PubMed
env HIV-1 gp41 peptide (amino acids 581-597) inhibits lymphoproliferation stimulated via the T-cell-activation molecules CD3, CD2, and CD28, as well as via direct stimulation mediated by phorbol ester combined with ionomycin PubMed
env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
Nef nef HIV-1 nef alleles from the great majority of primate lentiviruses, including HIV-2, downregulate TCR-CD3 from infected T cells and thereby block their responsiveness to activation PubMed
nef Expression of HIV-1 Tat and/or HIV-1 Nef in the absence of HIV-1 Rev leads to downregulation of CD3-gamma gene transcripts and TCR/CD3 surface density PubMed
nef Inhibition of T-cell migration of HIV-1 Nef expressing cells by CD3 stimulation results from the inhibition of surface expression of CXCR4 PubMed
nef HIV-1 Nef upregulates IL2 secretion when Jurkat cells are stimulated with both CD3 and CD28 PubMed
nef HIV-1 Nef interacts with CD3 in living cells PubMed
Pr55(Gag) gag Monocyte-derived macrophages selectively capture and engulf HIV-1-infected CD4+ T cells as HIV-1 Gag interacts with CD3 and Caspase 3 markers, leading to efficient macrophage infection PubMed
gag CD3/28-treated resting CD4+ T cells produce more HIV-1 Gag protein than untreated cells PubMed
gag Interferon-gamma can counteract the inhibitory effect of peptides based on the Capsid protein of HIV-1 Gag on antibody response to SRC PubMed
gag Peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation PubMed
gag Synthetic peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen through the T3-Ti complex PubMed
Tat tat HIV-1 Tat interacts with CD3 and CD28 to co-stimulate IL-2 and IL-8 expression PubMed
Vpu vpu HIV-1 Vpu interacts with CD3 in living cells PubMed
capsid gag Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to SRC PubMed
gag Peptides corresponding to amino acids 218-238 of HIV-1 Capsid inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation PubMed
gag Synthetic peptides corresponding to amino acids 218-238 of HIV-1 Capsid have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen through the T3-Ti complex PubMed
matrix gag HIV-1 MA co-localizes with CD3 marker protein in monocyte-derived macrophages cocultured with HIV-1-infected primary CD4+ T-cells PubMed
nucleocapsid gag HIV-1 NC upregulates CD3G antigen, gamma in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17620, FLJ17664, FLJ79544, FLJ94613, MGC138597

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of alpha-beta T cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of alpha-beta T cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
T-cell surface glycoprotein CD3 gamma chain
Names
CD3g antigen, gamma polypeptide (TiT3 complex)
CD3g molecule, epsilon (CD3-TCR complex)
CD3g molecule, gamma (CD3-TCR complex)
T-cell antigen receptor complex, gamma subunit of T3
T-cell receptor T3 gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007566.1 RefSeqGene

    Range
    5001..14439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_39

mRNA and Protein(s)

  1. NM_000073.3NP_000064.1  T-cell surface glycoprotein CD3 gamma chain precursor

    See identical proteins and their annotated locations for NP_000064.1

    Status: REVIEWED

    Source sequence(s)
    AK310622, AP001582, DB116263, DC378393, X04145
    Consensus CDS
    CCDS8395.1
    UniProtKB/Swiss-Prot
    P09693
    UniProtKB/TrEMBL
    B0YIY5
    Related
    ENSP00000431445.2, ENST00000532917.3
    Conserved Domains (3) summary
    pfam02189
    Location:157176
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam16680
    Location:39115
    Ig_4; T-cell surface glycoprotein CD3 delta chain
    cd07691
    Location:4246
    IgC1_CD3_gamma_delta; Ig strand B [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    118344344..118355161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718941.3XP_006719004.1  T-cell surface glycoprotein CD3 gamma chain isoform X2

    See identical proteins and their annotated locations for XP_006719004.1

    UniProtKB/Swiss-Prot
    P09693
    UniProtKB/TrEMBL
    B0YIY5
    Conserved Domains (3) summary
    pfam02189
    Location:157176
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam16680
    Location:39115
    Ig_4; T-cell surface glycoprotein CD3 delta chain
    cd07691
    Location:4246
    IgC1_CD3_gamma_delta; Ig strand B [structural motif]
  2. XM_005271724.4XP_005271781.1  T-cell surface glycoprotein CD3 gamma chain isoform X1

    Related
    ENST00000527777.5
    Conserved Domains (1) summary
    pfam16680
    Location:40106
    Ig_4; T-cell surface glycoprotein CD3 delta chain
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