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LONRF1 LON peptidase N-terminal domain and ring finger 1 [ Homo sapiens (human) ]

Gene ID: 91694, updated on 25-Nov-2021

Summary

Official Symbol
LONRF1provided by HGNC
Official Full Name
LON peptidase N-terminal domain and ring finger 1provided by HGNC
Primary source
HGNC:HGNC:26302
See related
Ensembl:ENSG00000154359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF191
Expression
Ubiquitous expression in skin (RPKM 19.9), fat (RPKM 10.6) and 25 other tissues See more
Orthologs
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Genomic context

See LONRF1 in Genome Data Viewer
Location:
8p23.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (12721900..12755526, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (12579415..12613035, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 10 pseudogene Neighboring gene microRNA 5692a-2 Neighboring gene microRNA 3926-1 Neighboring gene microRNA 3926-2 Neighboring gene uncharacterized LOC340357 Neighboring gene long intergenic non-protein coding RNA 681 Neighboring gene uncharacterized LOC105379289

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23749

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
LON peptidase N-terminal domain and RING finger protein 1
Names
RING finger protein 191

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329976.2NP_001316905.1  LON peptidase N-terminal domain and RING finger protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC123777
    UniProtKB/Swiss-Prot
    Q17RB8
    Conserved Domains (5) summary
    cd00162
    Location:467509
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:553754
    LON; Found in ATP-dependent protease La (LON)
    sd00006
    Location:247273
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:556754
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13432
    Location:251311
    TPR_16; Tetratricopeptide repeat
  2. NM_152271.5NP_689484.3  LON peptidase N-terminal domain and RING finger protein 1 isoform 1

    See identical proteins and their annotated locations for NP_689484.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123777
    Consensus CDS
    CCDS5987.2
    UniProtKB/Swiss-Prot
    Q17RB8
    Related
    ENSP00000381298.3, ENST00000398246.8
    Conserved Domains (5) summary
    cd00162
    Location:478520
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:564765
    LON; Found in ATP-dependent protease La (LON)
    sd00006
    Location:247273
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:567765
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13432
    Location:251311
    TPR_16; Tetratricopeptide repeat

RNA

  1. NR_138255.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123777
  2. NR_138256.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123777

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    12721900..12755526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544694.3XP_011542996.1  LON peptidase N-terminal domain and RING finger protein 1 isoform X1

    Conserved Domains (5) summary
    cd00162
    Location:247289
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:333534
    LON; Found in ATP-dependent protease La (LON)
    sd00006
    Location:1343
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:336534
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13432
    Location:2080
    TPR_16; Tetratricopeptide repeat

RNA

  1. XR_002956652.1 RNA Sequence

  2. XR_002956651.1 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    5917253..5950889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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