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MYADM myeloid associated differentiation marker [ Homo sapiens (human) ]

Gene ID: 91663, updated on 19-Sep-2024

Summary

Official Symbol
MYADMprovided by HGNC
Official Full Name
myeloid associated differentiation markerprovided by HGNC
Primary source
HGNC:HGNC:7544
See related
Ensembl:ENSG00000179820 MIM:609959; AllianceGenome:HGNC:7544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SB135
Summary
Involved in several processes, including negative regulation of heterotypic cell-cell adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein kinase C signaling. Located in several cellular components, including cortical actin cytoskeleton; membrane raft; and ruffle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung (RPKM 50.4), gall bladder (RPKM 50.0) and 25 other tissues See more
Orthologs
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Genomic context

See MYADM in Genome Data Viewer
Location:
19q13.42
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53865628..53876435)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56945407..56956143)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54368882..54379689)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54295400-54295900 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54295901-54296401 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54300296-54300796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54301378-54301878 Neighboring gene microRNA 373 Neighboring gene NLR family pyrin domain containing 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54332809-54333578 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54334349-54335116 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54335887-54336656 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54337427-54338194 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:54339735-54340504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54342811-54343580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54343581-54344348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54361270-54361770 Neighboring gene MYADM antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54369942-54370917 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54372027-54372940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54372941-54373854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54385903-54386454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54395841-54396380 Neighboring gene protein kinase C gamma Neighboring gene Sharpr-MPRA regulatory region 4174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54410617-54411158 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 7 Neighboring gene MPRA-validated peak3551 silencer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • AC008440.10

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myeloid-associated differentiation marker
Names
myeloid upregulated protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020818.2NP_001018654.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001018654.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, HY124929
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000375648.2, ENST00000391768.2
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  2. NM_001020819.3NP_001018655.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001018655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DA027466
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000375651.1, ENST00000391771.1
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  3. NM_001020820.3NP_001018656.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001018656.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, BX393859, DC379591
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000398269.2, ENST00000421337.6
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  4. NM_001020821.2NP_001018657.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001018657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, HY124929
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000375649.2, ENST00000391769.2
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  5. NM_001290188.2NP_001277117.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DC379591
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  6. NM_001290189.1NP_001277118.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents the longest transcript. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DB448983, HY124929
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  7. NM_001290190.2NP_001277119.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DA677314
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  8. NM_001290191.2NP_001277120.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DA472260
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  9. NM_001290192.2NP_001277121.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, BQ716724, DA948116
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  10. NM_001290193.2NP_001277122.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, BQ430033
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  11. NM_001290194.2NP_001277123.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, AL524210, DA948116
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000416919.1, ENST00000439000.5
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain
  12. NM_138373.5NP_612382.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_612382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DA948116
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000375650.4, ENST00000391770.9
    Conserved Domains (1) summary
    pfam01284
    Location:168312
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53865628..53876435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56945407..56956143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)