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EBAG9 estrogen receptor binding site associated antigen 9 [ Homo sapiens (human) ]

Gene ID: 9166, updated on 7-Jun-2020

Summary

Official Symbol
EBAG9provided by HGNC
Official Full Name
estrogen receptor binding site associated antigen 9provided by HGNC
Primary source
HGNC:HGNC:3123
See related
Ensembl:ENSG00000147654 MIM:605772
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EB9; PDAF
Summary
This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor, which binds to the estrogen-responsive element found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in thyroid (RPKM 14.2), adrenal (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See EBAG9 in Genome Data Viewer
Location:
8q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (109539700..109565996)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (110551929..110578225)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene PKHD1 like 1 Neighboring gene suppressor of cytokine signaling 5 pseudogene Neighboring gene mitogen-activated protein kinase 6 pseudogene 5 Neighboring gene syntabulin Neighboring gene uncharacterized LOC100132813 Neighboring gene SMG5 nonsense mediated mRNA decay factor pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat significantly increases the mRNA transcription levels and the secretion of soluble RCAS1 in CD4(+) T cells and monocytes. Tat-mediated apoptosis is blocked by inhibiting the expression of RCAS1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase activator activity involved in apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
receptor-binding cancer antigen expressed on SiSo cells
Names
cancer-associated surface antigen RCAS1
estrogen receptor-binding fragment-associated gene 9 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278938.1NP_001265867.1  receptor-binding cancer antigen expressed on SiSo cells

    See identical proteins and their annotated locations for NP_001265867.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA812215, AI619447, BC017729, BC022506, BG616704
    Consensus CDS
    CCDS6313.1
    UniProtKB/Swiss-Prot
    O00559
    UniProtKB/TrEMBL
    A0A024R9E0
    Related
    ENSP00000477645.1, ENST00000620557.4
    Conserved Domains (1) summary
    pfam07946
    Location:160203
    DUF1682; Protein of unknown function (DUF1682)
  2. NM_004215.5NP_004206.1  receptor-binding cancer antigen expressed on SiSo cells

    See identical proteins and their annotated locations for NP_004206.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA812215, AI619447, BC022506, CD108096
    Consensus CDS
    CCDS6313.1
    UniProtKB/Swiss-Prot
    O00559
    UniProtKB/TrEMBL
    A0A024R9E0
    Related
    ENSP00000337675.5, ENST00000337573.10
    Conserved Domains (1) summary
    pfam07946
    Location:160203
    DUF1682; Protein of unknown function (DUF1682)
  3. NM_198120.2NP_936056.1  receptor-binding cancer antigen expressed on SiSo cells

    See identical proteins and their annotated locations for NP_936056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA812215, AI619447, BC017729, BC022506, BG707115
    Consensus CDS
    CCDS6313.1
    UniProtKB/Swiss-Prot
    O00559
    UniProtKB/TrEMBL
    A0A024R9E0
    Related
    ENSP00000379131.2, ENST00000395785.6
    Conserved Domains (1) summary
    pfam07946
    Location:160203
    DUF1682; Protein of unknown function (DUF1682)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    109539700..109565996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013960.1XP_016869449.1  receptor-binding cancer antigen expressed on SiSo cells isoform X1

    UniProtKB/Swiss-Prot
    O00559
    UniProtKB/TrEMBL
    A0A024R9E0
    Related
    ENSP00000477734.1, ENST00000614147.1
    Conserved Domains (1) summary
    pfam07946
    Location:160203
    DUF1682; Protein of unknown function (DUF1682)
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