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DEPDC7 DEP domain containing 7 [ Homo sapiens (human) ]

Gene ID: 91614, updated on 12-Oct-2019

Summary

Official Symbol
DEPDC7provided by HGNC
Official Full Name
DEP domain containing 7provided by HGNC
Primary source
HGNC:HGNC:29899
See related
Ensembl:ENSG00000121690 MIM:612294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR2; dJ85M6.4
Expression
Biased expression in liver (RPKM 15.2), testis (RPKM 15.0) and 9 other tissues See more
Orthologs

Genomic context

See DEPDC7 in Genome Data Viewer
Location:
11p13
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (33015878..33033582)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33037410..33055128)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene proline rich and Gla domain 4 Neighboring gene glutamine and serine rich 1 Neighboring gene uncharacterized LOC105376615 Neighboring gene t-complex 11 like 1 Neighboring gene long intergenic non-protein coding RNA 294 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class C pseudogene 1 Neighboring gene cleavage stimulation factor subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DEP domain-containing protein 7
Names
dJ85M6.4 (novel 58.3 KDA protein)
novel 58.3 KDA protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077242.2NP_001070710.1  DEP domain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001070710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the more frequently occurring transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AJ245600, BC030970
    Consensus CDS
    CCDS41632.1
    UniProtKB/Swiss-Prot
    Q96QD5
    Related
    ENSP00000241051.3, ENST00000241051.8
    Conserved Domains (2) summary
    cd04405
    Location:194427
    RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
    cd04446
    Location:39133
    DEP_DEPDC4; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.
  2. NM_139160.2NP_631899.2  DEP domain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_631899.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes a different segment for the 5' UTR and 5' CDS, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC107939, AJ245600, BC030970
    Consensus CDS
    CCDS41633.1
    UniProtKB/Swiss-Prot
    Q96QD5
    Related
    ENSP00000308971.3, ENST00000311388.7
    Conserved Domains (2) summary
    cd04405
    Location:185418
    RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
    cd04446
    Location:30124
    DEP_DEPDC4; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    33015878..33033582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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