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FIBP FGF1 intracellular binding protein [ Homo sapiens (human) ]

Gene ID: 9158, updated on 7-Jun-2020

Summary

Official Symbol
FIBPprovided by HGNC
Official Full Name
FGF1 intracellular binding proteinprovided by HGNC
Primary source
HGNC:HGNC:3705
See related
Ensembl:ENSG00000172500 MIM:608296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FGFIBP; FIBP-1; TROFAS
Summary
Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 27.1), brain (RPKM 21.5) and 25 other tissues See more
Orthologs

Genomic context

See FIBP in Genome Data Viewer
Location:
11q13.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65883740..65888510, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65651211..65656010, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene sorting nexin 32 Neighboring gene cofilin 1 Neighboring gene MUS81 structure-specific endonuclease subunit Neighboring gene EGF containing fibulin extracellular matrix protein 2 Neighboring gene cathepsin W Neighboring gene coiled-coil domain containing 85B Neighboring gene FOS like 1, AP-1 transcription factor subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Thauvin-Robinet-Faivre syndrome
MedGen: C4310715 OMIM: 617107 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
acidic fibroblast growth factor intracellular-binding protein
Names
aFGF intracellular-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047103.1 RefSeqGene

    Range
    5069..9800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004214.5NP_004205.2  acidic fibroblast growth factor intracellular-binding protein isoform b

    See identical proteins and their annotated locations for NP_004205.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AI925637, BC017448, CD109589
    Consensus CDS
    CCDS8118.1
    UniProtKB/Swiss-Prot
    O43427
    Related
    ENSP00000350124.4, ENST00000357519.8
    Conserved Domains (1) summary
    pfam05427
    Location:3356
    FIBP; Acidic fibroblast growth factor binding (FIBP)
  2. NM_198897.2NP_942600.1  acidic fibroblast growth factor intracellular-binding protein isoform a

    See identical proteins and their annotated locations for NP_942600.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF250391, AI925637, CD109589
    Consensus CDS
    CCDS8119.1
    UniProtKB/Swiss-Prot
    O43427
    Related
    ENSP00000344572.2, ENST00000338369.6
    Conserved Domains (1) summary
    pfam05427
    Location:3363
    FIBP; Acidic fibroblast growth factor binding (FIBP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65883740..65888510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448763.1XP_024304531.1  acidic fibroblast growth factor intracellular-binding protein isoform X1

    Conserved Domains (1) summary
    pfam05427
    Location:54246
    FIBP; Acidic fibroblast growth factor binding (FIBP)

RNA

  1. XR_001748030.2 RNA Sequence

    Related
    ENST00000533037.5
  2. XR_950100.2 RNA Sequence

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