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UBXN11 UBX domain protein 11 [ Homo sapiens (human) ]

Gene ID: 91544, updated on 13-Mar-2020

Summary

Official Symbol
UBXN11provided by HGNC
Official Full Name
UBX domain protein 11provided by HGNC
Primary source
HGNC:HGNC:30600
See related
Ensembl:ENSG00000158062 MIM:609151
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOC; SOCI; COA-1; UBXD5; PP2243
Summary
This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 18.9), spleen (RPKM 17.6) and 25 other tissues See more
Orthologs

Genomic context

See UBXN11 in Genome Data Viewer
Location:
1p36.11
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (26282282..26318265, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26608773..26644756, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene centrosomal protein 85 Neighboring gene mitochondrial ribosomal protein S6 pseudogene 1 Neighboring gene SH3 domain binding glutamate rich protein like 3 Neighboring gene CD52 molecule Neighboring gene crystallin beta-gamma domain containing 2 Neighboring gene ribosomal protein L34 pseudogene 4 Neighboring gene zinc finger protein 683

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • DKFZp686F04228

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
UBX domain-containing protein 11
Names
UBX domain-containing protein 5
colorectal tumor-associated antigen COA-1
colorectal tumor-associated antigen-1
socius

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028986.1 RefSeqGene

    Range
    5001..40984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001077262.1NP_001070730.1  UBX domain-containing protein 11 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame group of four exons in the coding region, compared to variant 2. The resulting protein (isoform 3) is shorter than isoform 2.
    Source sequence(s)
    AF520989, AK094198, BM987787, DA989799
    Consensus CDS
    CCDS41287.1
    UniProtKB/Swiss-Prot
    Q5T124
    Related
    ENSP00000324721.7, ENST00000314675.11
    Conserved Domains (2) summary
    pfam08059
    Location:115185
    SEP; SEP domain
    cl00155
    Location:275343
    UBQ; Ubiquitin-like proteins
  2. NM_145345.2NP_663320.2  UBX domain-containing protein 11 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 2. The resulting protein (isoform 1) is shorter than isoform 2.
    Source sequence(s)
    AF520989, AK097368, BM987787
    Consensus CDS
    CCDS41286.1
    UniProtKB/Swiss-Prot
    Q5T124
    Related
    ENSP00000363334.2, ENST00000374217.6
    Conserved Domains (3) summary
    pfam08059
    Location:202272
    SEP; SEP domain
    cl00155
    Location:362430
    UBQ; Ubiquitin-like proteins
    cl21454
    Location:141195
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_183008.2NP_892120.2  UBX domain-containing protein 11 isoform 2

    See identical proteins and their annotated locations for NP_892120.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AF520989, AK093258, BM987787, DA421971, DA989799
    Consensus CDS
    CCDS41288.1
    UniProtKB/Swiss-Prot
    Q5T124
    Related
    ENSP00000363338.3, ENST00000374221.7
    Conserved Domains (3) summary
    pfam08059
    Location:235305
    SEP; SEP domain
    cl00155
    Location:395463
    UBQ; Ubiquitin-like proteins
    cl21454
    Location:174228
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    26282282..26318265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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