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PCED1B PC-esterase domain containing 1B [ Homo sapiens (human) ]

Gene ID: 91523, updated on 1-Jun-2020

Summary

Official Symbol
PCED1Bprovided by HGNC
Official Full Name
PC-esterase domain containing 1Bprovided by HGNC
Primary source
HGNC:HGNC:28255
See related
Ensembl:ENSG00000179715
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM113B
Summary
This gene encodes a protein that belongs to the GDSL/SGNH-like acyl-esterase family. Members of this family are hydrolases thought to function in modification of biopolymers on the cell surface. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Expression
Broad expression in lymph node (RPKM 6.5), adrenal (RPKM 4.1) and 19 other tissues See more
Orthologs

Genomic context

See PCED1B in Genome Data Viewer
Location:
12q13.11
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (47079603..47236663)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (47473386..47630446)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 38 member 4 Neighboring gene uncharacterized LOC107984466 Neighboring gene adhesion molecule with Ig like domain 2 Neighboring gene IFITM3P pseudogene 6 Neighboring gene PCED1B antisense RNA 1 Neighboring gene microRNA 4698 Neighboring gene uncharacterized LOC105369746 Neighboring gene uncharacterized LOC105369747

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC16044

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
PC-esterase domain-containing protein 1B
Names
family with sequence similarity 113, member B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281429.1NP_001268358.1  PC-esterase domain-containing protein 1B

    See identical proteins and their annotated locations for NP_001268358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC072670, BM545125, CR985281
    Consensus CDS
    CCDS8752.1
    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Related
    ENSP00000396040.1, ENST00000432328.2
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  2. NM_138371.3NP_612380.1  PC-esterase domain-containing protein 1B

    See identical proteins and their annotated locations for NP_612380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC072670, CR985281
    Consensus CDS
    CCDS8752.1
    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Related
    ENSP00000446688.1, ENST00000546455.6
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    47079603..47236663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269224.5XP_005269281.1  PC-esterase domain-containing protein 1B isoform X1

    See identical proteins and their annotated locations for XP_005269281.1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  2. XM_017020208.1XP_016875697.1  PC-esterase domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  3. XM_017020214.1XP_016875703.1  PC-esterase domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  4. XM_017020213.1XP_016875702.1  PC-esterase domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  5. XM_017020215.1XP_016875704.1  PC-esterase domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  6. XM_017020207.1XP_016875696.1  PC-esterase domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  7. XM_011538978.2XP_011537280.1  PC-esterase domain-containing protein 1B isoform X1

    See identical proteins and their annotated locations for XP_011537280.1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  8. XM_017020209.1XP_016875698.1  PC-esterase domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  9. XM_017020210.1XP_016875699.1  PC-esterase domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  10. XM_017020216.1XP_016875705.1  PC-esterase domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  11. XM_017020211.1XP_016875700.1  PC-esterase domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
  12. XM_017020212.1XP_016875701.1  PC-esterase domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q96HM7
    UniProtKB/TrEMBL
    A0A024R115
    Conserved Domains (1) summary
    cl01053
    Location:17249
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
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