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NEURL1 neuralized E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 9148, updated on 22-Sep-2022

Summary

Official Symbol
NEURL1provided by HGNC
Official Full Name
neuralized E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:7761
See related
Ensembl:ENSG00000107954 MIM:603804; AllianceGenome:HGNC:7761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
neu; NEUR1; NEURL; RNF67; neu-1; bA416N2.1
Summary
Predicted to enable translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in negative regulation of Notch signaling pathway; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 4.6), colon (RPKM 2.4) and 15 other tissues See more
Orthologs
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Genomic context

See NEURL1 in Genome Data Viewer
Location:
10q24.33
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (103493705..103592546)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (104381009..104479861)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105253462..105352303)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902494 Neighboring gene calcium homeostasis modulator 1 Neighboring gene NEURL1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 14515 Neighboring gene calcium homeostasis modulator 3 Neighboring gene uncharacterized LOC124902496 Neighboring gene Sharpr-MPRA regulatory region 3797 Neighboring gene Sharpr-MPRA regulatory region 15000 Neighboring gene SH3 and PX domains 2A Neighboring gene Sharpr-MPRA regulatory region 2777

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables translation factor activity, non-nucleic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lactation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of long-term neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in sperm axoneme assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase NEURL1
Names
RING finger protein 67
RING-type E3 ubiquitin transferase NEURL1
h-neuralized 1
neuralized homolog
neuralized-like protein 1A
NP_004201.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004210.5NP_004201.3  E3 ubiquitin-protein ligase NEURL1

    See identical proteins and their annotated locations for NP_004201.3

    Status: VALIDATED

    Source sequence(s)
    AK299620, AL121929, AL139339, U87864
    Consensus CDS
    CCDS7551.1
    UniProtKB/Swiss-Prot
    O76050, Q9H463
    UniProtKB/TrEMBL
    B4DS86
    Related
    ENSP00000358795.4, ENST00000369780.9
    Conserved Domains (3) summary
    smart00588
    Location:61183
    NEUZ; domain in neuralized proteins
    cd16785
    Location:519562
    mRING-HC-C3HC5_NEU1A; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein 1A (NEURL1A) and similar proteins
    pfam07177
    Location:296447
    Neuralized

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    103493705..103592546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    104381009..104479861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)