Format

Send to:

Choose Destination

NEURL1 neuralized E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 9148, updated on 29-Mar-2020

Summary

Official Symbol
NEURL1provided by HGNC
Official Full Name
neuralized E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:7761
See related
Ensembl:ENSG00000107954 MIM:603804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
neu; NEUR1; NEURL; RNF67; neu-1; bA416N2.1
Expression
Broad expression in brain (RPKM 4.6), colon (RPKM 2.4) and 15 other tissues See more
Orthologs

Genomic context

See NEURL1 in Genome Data Viewer
Location:
10q24.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (103493705..103592546)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105253735..105352309)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene calcium homeostasis modulator 1 Neighboring gene NEURL1 antisense RNA 1 Neighboring gene calcium homeostasis modulator 3 Neighboring gene Sharpr-MPRA regulatory region 15000 Neighboring gene SH3 and PX domains 2A Neighboring gene Sharpr-MPRA regulatory region 2777

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
translation factor activity, non-nucleic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of long-term neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
sperm axoneme assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase NEURL1
Names
RING finger protein 67
RING-type E3 ubiquitin transferase NEURL1
h-neuralized 1
neuralized homolog
neuralized-like protein 1A
NP_004201.3
XP_005270326.1
XP_005270327.1
XP_011538633.1
XP_011538634.1
XP_011538635.1
XP_011538637.1
XP_016872398.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004210.5NP_004201.3  E3 ubiquitin-protein ligase NEURL1

    See identical proteins and their annotated locations for NP_004201.3

    Status: VALIDATED

    Source sequence(s)
    AK299620, AL121929, AL139339, U87864
    Consensus CDS
    CCDS7551.1
    UniProtKB/Swiss-Prot
    O76050
    UniProtKB/TrEMBL
    B4DS86
    Related
    ENSP00000358795.4, ENST00000369780.8
    Conserved Domains (3) summary
    smart00588
    Location:61183
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:296447
    Neuralized; Neuralized
    cd16785
    Location:519562
    mRING-HC-C3HC5_NEU1A; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein 1A (NEURL1A) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    103493705..103592546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540331.3XP_011538633.1  E3 ubiquitin-protein ligase NEURL1 isoform X1

    Conserved Domains (4) summary
    smart00588
    Location:99221
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:103168
    Neuralized; Neuralized
    pfam13920
    Location:556605
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:333484
    SPRY; SPRY domain
  2. XM_011540335.3XP_011538637.1  E3 ubiquitin-protein ligase NEURL1 isoform X7

    Conserved Domains (3) summary
    smart00588
    Location:99221
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:103168
    Neuralized; Neuralized
    cl02614
    Location:103251
    SPRY; SPRY domain
  3. XM_017016909.2XP_016872398.1  E3 ubiquitin-protein ligase NEURL1 isoform X3

  4. XM_011540332.2XP_011538634.1  E3 ubiquitin-protein ligase NEURL1 isoform X2

    Conserved Domains (4) summary
    smart00588
    Location:81203
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:85150
    Neuralized; Neuralized
    pfam13920
    Location:538587
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:315466
    SPRY; SPRY domain
  5. XM_011540333.2XP_011538635.1  E3 ubiquitin-protein ligase NEURL1 isoform X5

    Conserved Domains (4) summary
    smart00588
    Location:43165
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:47112
    Neuralized; Neuralized
    pfam13920
    Location:500549
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:277428
    SPRY; SPRY domain
  6. XM_005270269.4XP_005270326.1  E3 ubiquitin-protein ligase NEURL1 isoform X4

    See identical proteins and their annotated locations for XP_005270326.1

    UniProtKB/Swiss-Prot
    O76050
    Conserved Domains (3) summary
    smart00588
    Location:44166
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:279430
    Neuralized; Neuralized
    cd16785
    Location:502545
    mRING-HC-C3HC5_NEU1A; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein 1A (NEURL1A) and similar proteins
  7. XM_005270270.4XP_005270327.1  E3 ubiquitin-protein ligase NEURL1 isoform X6

    See identical proteins and their annotated locations for XP_005270327.1

    Conserved Domains (3) summary
    smart00588
    Location:1108
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:221372
    Neuralized; Neuralized
    cd16785
    Location:444487
    mRING-HC-C3HC5_NEU1A; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein 1A (NEURL1A) and similar proteins

RNA

  1. XR_945866.2 RNA Sequence

Support Center