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NEMF nuclear export mediator factor [ Homo sapiens (human) ]

Gene ID: 9147, updated on 4-Nov-2018

Summary

Official Symbol
NEMFprovided by HGNC
Official Full Name
nuclear export mediator factorprovided by HGNC
Primary source
HGNC:HGNC:10663
See related
Ensembl:ENSG00000165525 MIM:608378; Vega:OTTHUMG00000170857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NY-CO-1; SDCCAG1
Summary
This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in brain (RPKM 12.2), thyroid (RPKM 10.8) and 25 other tissues See more
Orthologs

Genomic context

See NEMF in Genome Data Viewer
Location:
14q21.3
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (49782083..49853203, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (50250528..50319763, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon 2, accessory subunit Neighboring gene RNA, U6atac small nuclear 30, pseudogene Neighboring gene kelch domain containing 1 Neighboring gene kelch domain containing 2 Neighboring gene RNA, U6 small nuclear 539, pseudogene Neighboring gene uncharacterized LOC105378179 Neighboring gene RNA, 7SL, cytoplasmic 3 Neighboring gene RNA, 7SL, cytoplasmic 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
nuclear export IMP
Inferred from Mutant Phenotype
more info
PubMed 
rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome-associated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
RQC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear export mediator factor NEMF
Names
antigen NY-CO-1
serologically defined colon cancer antigen 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051075.1 RefSeqGene

    Range
    5001..74683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001301732.2NP_001288661.1  nuclear export mediator factor NEMF isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA602297, AK295010, AK304695, BC064364, CB112336, DC382921, DC396239
    UniProtKB/Swiss-Prot
    O60524
    Conserved Domains (4) summary
    COG1293
    Location:1623
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
    pfam05670
    Location:532585
    DUF814; Domain of unknown function (DUF814)
    pfam11923
    Location:9471046
    DUF3441; Domain of unknown function (DUF3441)
    cl22451
    Location:637755
    ASF1_hist_chap; ASF1 like histone chaperone
  2. NM_004713.5NP_004704.2  nuclear export mediator factor NEMF isoform 1

    See identical proteins and their annotated locations for NP_004704.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA602297, AK000913, BC064364, BX640807, CB112336, DA899175, DC382921, DC396239
    Consensus CDS
    CCDS9694.1
    UniProtKB/Swiss-Prot
    O60524
    Related
    ENSP00000298310.5, OTTHUMP00000244631, ENST00000298310.9, OTTHUMT00000410798
    Conserved Domains (4) summary
    COG1293
    Location:1644
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
    pfam05670
    Location:532606
    DUF814; Domain of unknown function (DUF814)
    pfam11923
    Location:9681067
    DUF3441; Domain of unknown function (DUF3441)
    cl22451
    Location:658776
    ASF1_hist_chap; ASF1 like histone chaperone

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    49782083..49853203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021760.2XP_016877249.1  nuclear export mediator factor NEMF isoform X1

    Conserved Domains (4) summary
    COG1293
    Location:49415
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
    pfam05670
    Location:303377
    DUF814; Domain of unknown function (DUF814)
    pfam11923
    Location:739838
    DUF3441; Domain of unknown function (DUF3441)
    cl22451
    Location:429547
    ASF1_hist_chap; ASF1 like histone chaperone
  2. XM_017021761.1XP_016877250.1  nuclear export mediator factor NEMF isoform X1

    Conserved Domains (4) summary
    COG1293
    Location:49415
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
    pfam05670
    Location:303377
    DUF814; Domain of unknown function (DUF814)
    pfam11923
    Location:739838
    DUF3441; Domain of unknown function (DUF3441)
    cl22451
    Location:429547
    ASF1_hist_chap; ASF1 like histone chaperone
  3. XM_011537317.3XP_011535619.1  nuclear export mediator factor NEMF isoform X2

    Conserved Domains (2) summary
    COG1293
    Location:1580
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
    pfam05670
    Location:532582
    DUF814; Domain of unknown function (DUF814)
  4. XM_011537318.3XP_011535620.1  nuclear export mediator factor NEMF isoform X3

    Conserved Domains (1) summary
    COG1293
    Location:1400
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_001750595.2 RNA Sequence

  2. XR_943557.3 RNA Sequence

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