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ISX intestine specific homeobox [ Homo sapiens (human) ]

Gene ID: 91464, updated on 23-Nov-2021

Summary

Official Symbol
ISXprovided by HGNC
Official Full Name
intestine specific homeoboxprovided by HGNC
Primary source
HGNC:HGNC:28084
See related
Ensembl:ENSG00000175329 MIM:612019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pix-1; RAXLX
Summary
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 20.1), colon (RPKM 15.2) and 1 other tissue See more
Orthologs
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Genomic context

See ISX in Genome Data Viewer
Location:
22q12.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (35066158..35087387)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (35462151..35483380)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373014 Neighboring gene long intergenic non-protein coding RNA 2885 Neighboring gene uncharacterized LOC105373016 Neighboring gene uncharacterized LOC105373015 Neighboring gene long intergenic non-protein coding RNA 1399 Neighboring gene cytochrome c oxidase subunit 7B pseudogene 1 Neighboring gene uncharacterized LOC105373017 Neighboring gene RNA, U7 small nuclear 167 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138417, DKFZp781N2395

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in enteric nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
intestine-specific homeobox
Names
RAX-like homeobox
pancreas-intestine homeodomain transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303508.2NP_001290437.1  intestine-specific homeobox

    See identical proteins and their annotated locations for NP_001290437.1

    Status: VALIDATED

    Source sequence(s)
    AK025181, AL024494, CR749372, Z83853
    Consensus CDS
    CCDS33640.1
    UniProtKB/Swiss-Prot
    Q2M1V0
    Related
    ENSP00000386037.1, ENST00000404699.7
    Conserved Domains (1) summary
    pfam00046
    Location:86138
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    35066158..35087387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008494.1: Suppressed sequence

    Description
    NM_001008494.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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