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HGS hepatocyte growth factor-regulated tyrosine kinase substrate [ Homo sapiens (human) ]

Gene ID: 9146, updated on 5-Jul-2020

Summary

Official Symbol
HGSprovided by HGNC
Official Full Name
hepatocyte growth factor-regulated tyrosine kinase substrateprovided by HGNC
Primary source
HGNC:HGNC:4897
See related
Ensembl:ENSG00000185359 MIM:604375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRS
Summary
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in testis (RPKM 20.7), bone marrow (RPKM 16.1) and 25 other tissues See more
Orthologs

Genomic context

See HGS in Genome Data Viewer
Location:
17q25.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81684011..81702121)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79650962..79669151)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 137 Neighboring gene Sharpr-MPRA regulatory region 13823 Neighboring gene ADP ribosylation factor like GTPase 16 Neighboring gene microRNA 6786 Neighboring gene mitochondrial ribosomal protein L12 Neighboring gene solute carrier family 25 member 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Digital quantification of human eye color highlights genetic association of three new loci.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef co-localizes with CXCR4, AIP4, NEDD4, CD63/LAMP-1-positive vesicles, and HRS/VPS27-positive ESCRT-0 structures in HeLa cells PubMed
Pr55(Gag) gag Overexpression of the C-terminal fragment of HRS (residues 391-777) or HRS mutants lacking either the N-terminal FYVE domain (residues 215-290) or the PSAP (residues 348-351) motif efficiently inhibit HIV-1 Gag particle production PubMed
Vpu vpu Vpu interacts with HGS (HRS) via the HGS double-ubiquitin interaction motif, indicating this motif is the direct binding site for Vpu or ubiquitination of cargo mediates Vpu/HGS interaction or by factors associated in the degradation pathway PubMed
vpu Physiological levels of Vpu requires the core ESCRT pathway (TSG1010 and UBAP1) and HGA (HRS) for Vpu-mediated BST-2 (tetherin) degradation but does NOT require these proteins for counteraction of BST2 (tetherin's) physical antiviral activity PubMed
vpu HRS, an ESCRT-0 complex component, is required for the Vpu-induced downregulation of BST-2, indicating that Vpu-induced BST-2 degradation involves the ESCRT/MVB pathway PubMed
vpu HRS interacts with both HIV-1 Vpu and tetherin by co-precipitation analysis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11421, FLJ39878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endosomal transport NAS
Non-traceable Author Statement
more info
PubMed 
endosomal transport TAS
Traceable Author Statement
more info
 
macroautophagy TAS
Traceable Author Statement
more info
PubMed 
membrane invagination IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane organization TAS
Traceable Author Statement
more info
 
multivesicular body assembly TAS
Traceable Author Statement
more info
PubMed 
negative regulation of JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of exosomal secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
ESCRT-0 complex IDA
Inferred from Direct Assay
more info
PubMed 
ESCRT-0 complex TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosome IDA
Inferred from Direct Assay
more info
 
multivesicular body membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hepatocyte growth factor-regulated tyrosine kinase substrate
Names
human growth factor-regulated tyrosine kinase substrate
protein pp110

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004712.5NP_004703.1  hepatocyte growth factor-regulated tyrosine kinase substrate

    See identical proteins and their annotated locations for NP_004703.1

    Status: REVIEWED

    Source sequence(s)
    AI365104, BC003565
    Consensus CDS
    CCDS11784.1
    UniProtKB/Swiss-Prot
    O14964
    UniProtKB/TrEMBL
    A0A0S2Z4R4
    Related
    ENSP00000331201.4, ENST00000329138.9
    Conserved Domains (6) summary
    cd03569
    Location:4145
    VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...
    cd15720
    Location:159219
    FYVE_Hrs; FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins
    pfam07223
    Location:519746
    DUF1421; Protein of unknown function (DUF1421)
    pfam12210
    Location:407501
    Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate
    cd16269
    Location:531542
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:486560
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81684011..81702121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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