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BTF3L4 basic transcription factor 3 like 4 [ Homo sapiens (human) ]

Gene ID: 91408, updated on 3-Nov-2024

Summary

Official Symbol
BTF3L4provided by HGNC
Official Full Name
basic transcription factor 3 like 4provided by HGNC
Primary source
HGNC:HGNC:30547
See related
Ensembl:ENSG00000134717 AllianceGenome:HGNC:30547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 12.4), adrenal (RPKM 12.1) and 25 other tissues See more
Orthologs
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Genomic context

See BTF3L4 in Genome Data Viewer
Location:
1p32.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52056295..52090716)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (51937800..51972197)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (52521967..52556388)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1030 Neighboring gene thioredoxin domain containing 12 Neighboring gene TXNDC12 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:52520887-52521291 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:52521457-52522170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:52522171-52522882 Neighboring gene KTI12 chromatin associated homolog Neighboring gene collagen alpha-2(I) chain-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 885 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:52613533-52614066 Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide pseudogene Neighboring gene RNA, 7SL, cytoplasmic 788, pseudogene Neighboring gene zinc finger FYVE-type containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
transcription factor BTF3 homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136497.3NP_001129969.1  transcription factor BTF3 homolog 4 isoform 2

    See identical proteins and their annotated locations for NP_001129969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the exon containing the translation start codon compared to variant (1). The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK027582, AL139156, BU567198
    Consensus CDS
    CCDS44146.1
    UniProtKB/Swiss-Prot
    Q96K17
    Related
    ENSP00000436712.1, ENST00000472944.6
    Conserved Domains (1) summary
    cd22055
    Location:162
    NAC_BTF3; basal transcription factor BTF3
  2. NM_001243767.2NP_001230696.1  transcription factor BTF3 homolog 4 isoform 3

    See identical proteins and their annotated locations for NP_001230696.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL139156, DA369498
    Consensus CDS
    CCDS58001.1
    UniProtKB/Swiss-Prot
    Q96K17
    Related
    ENSP00000434824.1, ENST00000489308.6
  3. NM_152265.5NP_689478.1  transcription factor BTF3 homolog 4 isoform 1

    See identical proteins and their annotated locations for NP_689478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL139156, BC070378
    Consensus CDS
    CCDS30713.1
    UniProtKB/Swiss-Prot
    B3KNJ1, D3DQ32, G3V1C6, Q96K17
    UniProtKB/TrEMBL
    E9PL10
    Related
    ENSP00000360664.4, ENST00000313334.13
    Conserved Domains (1) summary
    cd22055
    Location:4120
    NAC_BTF3; basal transcription factor BTF3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    52056295..52090716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    51937800..51972197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)