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RRP9 ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [ Homo sapiens (human) ]

Gene ID: 9136, updated on 8-Nov-2020

Summary

Official Symbol
RRP9provided by HGNC
Official Full Name
ribosomal RNA processing 9, U3 small nucleolar RNA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16829
See related
Ensembl:ENSG00000114767
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
U3-55K; RNU3IP2
Summary
This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in appendix (RPKM 6.7), adrenal (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See RRP9 in Genome Data Viewer
Location:
3p21.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (51933429..51941904, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51967442..51975957, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene IQCF5 antisense RNA 1 Neighboring gene IQ motif containing F5 Neighboring gene IQ motif containing F1 Neighboring gene poly(ADP-ribose) polymerase family member 3 Neighboring gene G protein-coupled receptor 62 Neighboring gene poly(rC) binding protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
U3 snoRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to U3 snoRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
rRNA processing IC
Inferred by Curator
more info
PubMed 
rRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
box C/D snoRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
U3 small nucleolar RNA-interacting protein 2
Names
RNA, U3 small nucleolar interacting protein 2
RRP9 homolog
RRP9, small subunit (SSU) processome component, homolog
U3 small nucleolar ribonucleoprotein-associated 55 kDa protein
U3 snoRNP-associated 55-kDa protein
ribosomal RNA processing 9, small subunit (SSU) processome component, homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004704.5NP_004695.1  U3 small nucleolar RNA-interacting protein 2

    See identical proteins and their annotated locations for NP_004695.1

    Status: REVIEWED

    Source sequence(s)
    AA465355, AC115284, BC010048
    Consensus CDS
    CCDS2837.1
    UniProtKB/Swiss-Prot
    O43818
    Related
    ENSP00000232888.6, ENST00000232888.7
    Conserved Domains (3) summary
    COG2319
    Location:136403
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:139439
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:149197
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    51933429..51941904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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