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DDX60L DExD/H-box 60 like [ Homo sapiens (human) ]

Gene ID: 91351, updated on 23-Nov-2021

Summary

Official Symbol
DDX60Lprovided by HGNC
Official Full Name
DExD/H-box 60 likeprovided by HGNC
Primary source
HGNC:HGNC:26429
See related
Ensembl:ENSG00000181381 MIM:616725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in appendix (RPKM 7.8), bone marrow (RPKM 6.5) and 24 other tissues See more
Orthologs
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Genomic context

See DDX60L in Genome Data Viewer
Location:
4q32.3
Exon count:
46
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (168356735..168480514, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (169277886..169401643, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene annexin A10 Neighboring gene uncharacterized LOC105377524 Neighboring gene DExD/H-box helicase 60 Neighboring gene uncharacterized LOC107986198 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene basic transcription factor 3 like 4 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like (DDX60L) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13468, FLJ31033, FLJ39050, DKFZp781D1175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX60-like
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
DEAD box protein 60-like
DEAD-box helicase 60 like
putative ATP-dependent RNA helicase DDX60
NP_001012985.2
NP_001278439.1
NP_001332856.1
NP_001364998.1
NP_001364999.1
NP_001365000.1
NP_001365001.1
XP_005263398.2
XP_005263400.2
XP_005263402.2
XP_006714471.1
XP_011530704.1
XP_011530705.1
XP_011530706.1
XP_011530707.1
XP_011530708.1
XP_011530711.1
XP_016864318.1
XP_016864319.1
XP_016864320.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051576.1 RefSeqGene

    Range
    5001..128780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012967.3NP_001012985.2  probable ATP-dependent RNA helicase DDX60-like isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC079926, AC093888, AK055595, AL832950, CR933601, DA553350, EB710202
    Consensus CDS
    CCDS47161.1
    UniProtKB/Swiss-Prot
    Q5H9U9
    Related
    ENSP00000507872.1, ENST00000682922.1
    Conserved Domains (2) summary
    smart00490
    Location:12381314
    HELICc; helicase superfamily c-terminal domain
    pfam00270
    Location:748902
    DEAD; DEAD/DEAH box helicase
  2. NM_001291510.2NP_001278439.1  probable ATP-dependent RNA helicase DDX60-like isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC079926, AC093888, AK092461, CR933601, DA553350
    UniProtKB/Swiss-Prot
    Q5H9U9
    Related
    ENSP00000422202.1, ENST00000505890.5
    Conserved Domains (2) summary
    smart00490
    Location:12391308
    HELICc; helicase superfamily c-terminal domain
    pfam00270
    Location:748902
    DEAD; DEAD/DEAH box helicase
  3. NM_001345927.2NP_001332856.1  probable ATP-dependent RNA helicase DDX60-like isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC079926, AC093888, KF457833
    Conserved Domains (2) summary
    COG4581
    Location:7421358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  4. NM_001378069.1NP_001364998.1  probable ATP-dependent RNA helicase DDX60-like isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC079926
  5. NM_001378070.1NP_001364999.1  probable ATP-dependent RNA helicase DDX60-like isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC079926
    Related
    ENSP00000424396.1, ENST00000514748.5
  6. NM_001378071.1NP_001365000.1  probable ATP-dependent RNA helicase DDX60-like isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC079926
  7. NM_001378072.1NP_001365001.1  probable ATP-dependent RNA helicase DDX60-like isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC079926, AC093888, KF457833
    Conserved Domains (2) summary
    COG4581
    Location:7421358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    168356735..168480514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532405.1XP_011530707.1  probable ATP-dependent RNA helicase DDX60-like isoform X3

    Conserved Domains (2) summary
    smart00490
    Location:12061282
    HELICc; helicase superfamily c-terminal domain
    cl21455
    Location:748812
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011532404.1XP_011530706.1  probable ATP-dependent RNA helicase DDX60-like isoform X2

    Conserved Domains (2) summary
    smart00490
    Location:12071283
    HELICc; helicase superfamily c-terminal domain
    cl21455
    Location:748812
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_017008830.1XP_016864319.1  probable ATP-dependent RNA helicase DDX60-like isoform X5

  4. XM_011532406.1XP_011530708.1  probable ATP-dependent RNA helicase DDX60-like isoform X4

    Conserved Domains (2) summary
    smart00490
    Location:12391315
    HELICc; helicase superfamily c-terminal domain
    pfam00270
    Location:748902
    DEAD; DEAD/DEAH box helicase
  5. XM_005263341.4XP_005263398.2  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_005263398.2

    Conserved Domains (2) summary
    COG4581
    Location:7421358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  6. XM_011532403.2XP_011530705.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_011530705.1

    Conserved Domains (2) summary
    COG4581
    Location:7421358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  7. XM_011532402.2XP_011530704.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_011530704.1

    Conserved Domains (2) summary
    COG4581
    Location:7421358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  8. XM_006714408.2XP_006714471.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_006714471.1

    Conserved Domains (2) summary
    COG4581
    Location:7421358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  9. XM_017008829.1XP_016864318.1  probable ATP-dependent RNA helicase DDX60-like isoform X2

    Conserved Domains (2) summary
    smart00490
    Location:12071283
    HELICc; helicase superfamily c-terminal domain
    cl21455
    Location:748812
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. XM_005263343.2XP_005263400.2  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_005263400.2

    Conserved Domains (2) summary
    COG4581
    Location:7421358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  11. XM_005263345.4XP_005263402.2  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_005263402.2

    Conserved Domains (2) summary
    COG4581
    Location:7421358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  12. XM_017008831.1XP_016864320.1  probable ATP-dependent RNA helicase DDX60-like isoform X6

    Conserved Domains (2) summary
    smart00490
    Location:625701
    HELICc; helicase superfamily c-terminal domain
    pfam00270
    Location:134288
    DEAD; DEAD/DEAH box helicase
  13. XM_011532409.3XP_011530711.1  probable ATP-dependent RNA helicase DDX60-like isoform X6

    See identical proteins and their annotated locations for XP_011530711.1

    Conserved Domains (2) summary
    smart00490
    Location:625701
    HELICc; helicase superfamily c-terminal domain
    pfam00270
    Location:134288
    DEAD; DEAD/DEAH box helicase

RNA

  1. XR_938792.1 RNA Sequence

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