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TMEM259 transmembrane protein 259 [ Homo sapiens (human) ]

Gene ID: 91304, updated on 23-Nov-2021

Summary

Official Symbol
TMEM259provided by HGNC
Official Full Name
transmembrane protein 259provided by HGNC
Primary source
HGNC:HGNC:17039
See related
Ensembl:ENSG00000182087 MIM:611011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MBRL; ASBABP1; C19orf6; R32184_3; MEMBRALIN
Expression
Ubiquitous expression in spleen (RPKM 49.2), fat (RPKM 38.4) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM259 in Genome Data Viewer
Location:
19p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1009651..1021142, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1009652..1021122, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene WD repeat domain 18 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3B Neighboring gene uncharacterized LOC105372235 Neighboring gene RNA, U6 small nuclear 2 Neighboring gene calponin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4022

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
membralin
Names
aspecific BCL2 ARE-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033026.2NP_001028198.1  membralin isoform 1

    See identical proteins and their annotated locations for NP_001028198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK090400, AK095756, BQ895919, DQ005958
    Consensus CDS
    CCDS32862.1
    UniProtKB/Swiss-Prot
    Q4ZIN3
    UniProtKB/TrEMBL
    B3KTL0
    Related
    ENSP00000349087.2, ENST00000356663.8
    Conserved Domains (1) summary
    pfam09746
    Location:35402
    Membralin; Tumour-associated protein
  2. NM_033420.4NP_219488.1  membralin isoform 2

    See identical proteins and their annotated locations for NP_219488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK090400, AK095756, BC008957, BQ895919
    Consensus CDS
    CCDS12052.1
    UniProtKB/Swiss-Prot
    Q4ZIN3
    UniProtKB/TrEMBL
    B3KTL0
    Related
    ENSP00000331423.4, ENST00000333175.9
    Conserved Domains (1) summary
    pfam09746
    Location:35402
    Membralin; Tumour-associated protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    1009651..1021142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451773.1XP_024307541.1  membralin isoform X6

    Conserved Domains (2) summary
    pfam09746
    Location:36385
    Membralin; tumor-associated protein
    cl26247
    Location:458603
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  2. XM_005259676.3XP_005259733.1  membralin isoform X2

    Conserved Domains (1) summary
    pfam09746
    Location:35402
    Membralin; Tumour-associated protein
  3. XM_017027457.2XP_016882946.1  membralin isoform X5

  4. XM_005259677.3XP_005259734.1  membralin isoform X3

    Conserved Domains (1) summary
    pfam09746
    Location:35391
    Membralin; Tumour-associated protein
  5. XM_005259678.3XP_005259735.1  membralin isoform X4

    Conserved Domains (1) summary
    pfam09746
    Location:35408
    Membralin; Tumour-associated protein
  6. XM_005259675.3XP_005259732.1  membralin isoform X1

    Conserved Domains (1) summary
    pfam09746
    Location:35408
    Membralin; Tumour-associated protein

RNA

  1. XR_430159.4 RNA Sequence

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