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LMF2 lipase maturation factor 2 [ Homo sapiens (human) ]

Gene ID: 91289, updated on 4-Dec-2022

Summary

Official Symbol
LMF2provided by HGNC
Official Full Name
lipase maturation factor 2provided by HGNC
Primary source
HGNC:HGNC:25096
See related
Ensembl:ENSG00000100258 AllianceGenome:HGNC:25096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM153; TMEM112B
Summary
Predicted to be involved in protein maturation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in pancreas (RPKM 20.5), spleen (RPKM 16.6) and 25 other tissues See more
Orthologs
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Genomic context

See LMF2 in Genome Data Viewer
Location:
22q13.33
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50502949..50507702, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (51013236..51018230, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50941378..50946131, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene adrenomedullin 2 Neighboring gene myo-inositol oxygenase Neighboring gene non-SMC condensin II complex subunit H2 Neighboring gene synthesis of cytochrome C oxidase 2 Neighboring gene thymidine phosphorylase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 

General protein information

Preferred Names
lipase maturation factor 2
Names
transmembrane protein 112B
transmembrane protein 153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363816.2NP_001350745.1  lipase maturation factor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC002942, BU628394, BX412067, HY053209, U62317
    Consensus CDS
    CCDS87035.1
    Related
    ENSP00000216080.5, ENST00000216080.5
    Conserved Domains (1) summary
    pfam06762
    Location:102563
    LMF1; Lipase maturation factor
  2. NM_033200.3NP_149977.2  lipase maturation factor 2 isoform 1

    See identical proteins and their annotated locations for NP_149977.2

    Status: VALIDATED

    Source sequence(s)
    BC002942, BI917400, BU628394, BX412067, U62317
    Consensus CDS
    CCDS14093.2
    UniProtKB/Swiss-Prot
    Q96C62, Q9BU23
    Related
    ENSP00000424381.1, ENST00000474879.7
    Conserved Domains (1) summary
    pfam06762
    Location:127588
    LMF1; Lipase maturation factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50502949..50507702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724426.4XP_006724489.1  lipase maturation factor 2 isoform X1

    See identical proteins and their annotated locations for XP_006724489.1

    Conserved Domains (1) summary
    pfam06762
    Location:142533
    LMF1; Lipase maturation factor
  2. XM_047441593.1XP_047297549.1  lipase maturation factor 2 isoform X3

  3. XM_047441592.1XP_047297548.1  lipase maturation factor 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    51013236..51018230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)