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BOD1 biorientation of chromosomes in cell division 1 [ Homo sapiens (human) ]

Gene ID: 91272, updated on 5-Aug-2022

Summary

Official Symbol
BOD1provided by HGNC
Official Full Name
biorientation of chromosomes in cell division 1provided by HGNC
Primary source
HGNC:HGNC:25114
See related
Ensembl:ENSG00000145919 MIM:616745; AllianceGenome:HGNC:25114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM44B
Summary
Enables protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Involved in mitotic sister chromatid segregation; negative regulation of phosphoprotein phosphatase activity; and protein localization to chromosome, centromeric region. Located in centrosome; spindle microtubule; and spindle pole. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 15.5), ovary (RPKM 14.9) and 25 other tissues See more
Orthologs
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Genomic context

See BOD1 in Genome Data Viewer
Location:
5q35.2
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (173607145..173616650, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (174147207..174156712, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (173034148..173043653, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377733 Neighboring gene long intergenic non-protein coding RNA 2995 Neighboring gene long intergenic non-protein coding RNA 1863 Neighboring gene long intergenic non-protein coding RNA 1942

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase 2A binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of outer kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
biorientation of chromosomes in cell division protein 1
Names
biorientation defective 1
family with sequence similarity 44, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159651.3NP_001153123.1  biorientation of chromosomes in cell division protein 1 isoform b

    See identical proteins and their annotated locations for NP_001153123.1

    Status: VALIDATED

    Source sequence(s)
    AC010339
    Consensus CDS
    CCDS54951.1
    UniProtKB/Swiss-Prot
    Q96IK1
    Related
    ENSP00000285908.5, ENST00000285908.5
    Conserved Domains (1) summary
    pfam05205
    Location:55121
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
  2. NM_138369.3NP_612378.1  biorientation of chromosomes in cell division protein 1 isoform a

    See identical proteins and their annotated locations for NP_612378.1

    Status: VALIDATED

    Source sequence(s)
    BC007436, BQ881883, DA506589
    Consensus CDS
    CCDS4389.1
    UniProtKB/Swiss-Prot
    Q96IK1, Q9BTW1
    Related
    ENSP00000309644.4, ENST00000311086.9
    Conserved Domains (1) summary
    pfam05205
    Location:55148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

RNA

  1. NR_164700.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010339
  2. NR_164701.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010339
  3. NR_164702.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010339
  4. NR_164703.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010339

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    173607145..173616650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    174147207..174156712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)