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SLC16A3 solute carrier family 16 member 3 [ Homo sapiens (human) ]

Gene ID: 9123, updated on 5-Jul-2020

Summary

Official Symbol
SLC16A3provided by HGNC
Official Full Name
solute carrier family 16 member 3provided by HGNC
Primary source
HGNC:HGNC:10924
See related
Ensembl:ENSG00000141526 MIM:603877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT3; MCT4; MCT 3; MCT 4; MCT-3; MCT-4
Summary
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in placenta (RPKM 10.2), appendix (RPKM 8.8) and 22 other tissues See more
Orthologs

Genomic context

See SLC16A3 in Genome Data Viewer
Location:
17q25.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (82217951..82240086)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80186282..80197375)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 134 Neighboring gene fatty acid synthase Neighboring gene coiled-coil domain containing 57 Neighboring gene Sharpr-MPRA regulatory region 14342 Neighboring gene microRNA 6787 Neighboring gene casein kinase 1 delta Neighboring gene CSNK1D-CD7 intergenic CAGE-defined low expression enhancer Neighboring gene long intergenic non-protein coding RNA 1970

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138472, MGC138474

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
lactate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
leukocyte migration TAS
Traceable Author Statement
more info
 
monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane lactate transport IEA
Inferred from Electronic Annotation
more info
 
pyruvate metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
monocarboxylate transporter 4
Names
monocarboxylate transporter 3
solute carrier family 16 (monocarboxylate transporter), member 3
solute carrier family 16 (monocarboxylic acid transporters), member 3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042422.2NP_001035887.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_001035887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AA448579, BC112269, BM926587, BM980920, DA419716
    Consensus CDS
    CCDS11804.1
    UniProtKB/Swiss-Prot
    O15427
    UniProtKB/TrEMBL
    A0A024R8U1
    Conserved Domains (1) summary
    cl26868
    Location:8444
    2A0111; oxalate/formate antiporter family transporter
  2. NM_001042423.2NP_001035888.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_001035888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AA448579, AC132872, BC112267, BM980920, CX872345
    Consensus CDS
    CCDS11804.1
    UniProtKB/Swiss-Prot
    O15427
    UniProtKB/TrEMBL
    A0A024R8U1
    Related
    ENSP00000376150.1, ENST00000392339.5
    Conserved Domains (1) summary
    cl26868
    Location:8444
    2A0111; oxalate/formate antiporter family transporter
  3. NM_001206950.1NP_001193879.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_001193879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AA448579, BC112267, BM926587, BM980920, DA583988
    Consensus CDS
    CCDS11804.1
    UniProtKB/Swiss-Prot
    O15427
    UniProtKB/TrEMBL
    A0A024R8U1
    Related
    ENSP00000376152.1, ENST00000392341.5
    Conserved Domains (1) summary
    cl26868
    Location:8444
    2A0111; oxalate/formate antiporter family transporter
  4. NM_001206951.1NP_001193880.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_001193880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AA448579, AC132872, BC112267, BM980920, DA373476
    Consensus CDS
    CCDS11804.1
    UniProtKB/Swiss-Prot
    O15427
    UniProtKB/TrEMBL
    A0A024R8U1
    Related
    ENSP00000483212.1, ENST00000617373.4
    Conserved Domains (1) summary
    cl26868
    Location:8444
    2A0111; oxalate/formate antiporter family transporter
  5. NM_001206952.1NP_001193881.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_001193881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AA448579, BC112267, BM980920, DA895850
    Consensus CDS
    CCDS11804.1
    UniProtKB/Swiss-Prot
    O15427
    UniProtKB/TrEMBL
    A0A024R8U1
    Related
    ENSP00000482013.1, ENST00000619321.1
    Conserved Domains (1) summary
    cl26868
    Location:8444
    2A0111; oxalate/formate antiporter family transporter
  6. NM_004207.4NP_004198.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_004198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC132872
    Consensus CDS
    CCDS11804.1
    UniProtKB/Swiss-Prot
    O15427
    UniProtKB/TrEMBL
    A0A024R8U1
    Related
    ENSP00000462405.1, ENST00000582743.5
    Conserved Domains (1) summary
    cl26868
    Location:8444
    2A0111; oxalate/formate antiporter family transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    82217951..82240086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451023.1XP_024306791.1  monocarboxylate transporter 4 isoform X1

    Conserved Domains (1) summary
    cl26868
    Location:8444
    2A0111; oxalate/formate antiporter family transporter
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