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HN hemagglutinin-neuraminidase [ Newcastle disease virus B1 ]

Gene ID: 912270, discontinued on 27-Aug-2018
  • This record was discontinued.
Gene symbol
HN
Gene description
hemagglutinin-neuraminidase
Locus tag
NDVgp5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Newcastle disease virus B1 (strain: B1)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Paramyxoviridae; Avulavirus
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Genomic Sequence:
NC_002617.1

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E347Q and G362K amino acid substitutions in HN are responsible for antigenic variation.
    Title: Identification of novel E347Q and G362K amino acid substitutions in HN neutralization epitope and major antigenic difference in novel sub-genotype VIIj isolates.
  2. Chicken CG-1B has anti-Newcastle disease virus activity by binding to N-glycans onNDV HN glycoprotein.
    Title: Chicken galectin-1B inhibits Newcastle disease virus adsorption and replication through binding to hemagglutinin-neuraminidase (HN) glycoprotein.
  3. These finding will form the basis for future quantitative glycomic studies of the distribution of glycan structures across N-linked glycosylation sites of Newcastle disease virus haemagglutinin-neuraminidase and assessment of the functional significance of the O-linked glycan in the stalk domain of this protein
    Title: Site-specific glycosylation of the Newcastle disease virus haemagglutinin-neuraminidase.
  4. Here, the authors have identified the flexible loop region connecting the bulky enzymatically active head and the four-helix bundle stalk to be essential for fusion promotion.
    Title: Flexibility of the Head-Stalk Linker Domain of Paramyxovirus HN Glycoprotein Is Essential for Triggering Virus Fusion.
  5. HN protein of Newcastle disease virus and TNF-alpha induce apoptosis in HeLa cells by downregulating NF-kappa B expression
    Title: HN protein of Newcastle disease virus sensitizes HeLa cells to TNF-α-induced apoptosis by downregulating NF-κB expression.
  6. HN Protein of Newcastle Disease Virus Induces Apoptosis Through SAPK/JNK Pathway
    Title: HN Protein of Newcastle Disease Virus Induces Apoptosis Through SAPK/JNK Pathway.
  7. It was proven that the headless HN protein of Newcastle disease virus could promote the fusion event mediated by F protein.
    Title: Roles of the highly conserved amino acids in the globular head and stalk region of the Newcastle disease virus HN protein in the membrane fusion process.
  8. Variations in amino acid 395, 523, 550 432, 479 and 540 of sialidase protein play an effective role in the pathogenesis.
    Title: Comparative analysis of sialidase protein in velogenic and lentogenic strains of Newcastle disease virus.
  9. HN activates the F protein such that virus-cell fusion is controlled.
    Title: Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells.
  10. The HN protein C-terminal extension contribute to the reduced virulence in some low virulence Newcastle disease virus. strains
    Title: Effects of the HN gene C-terminal extensions on the Newcastle disease virus virulence.
Submit: New GeneRIF Correction See all GeneRIFs (29)
Preferred Names
hemagglutinin-neuraminidase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002617.1 Reference assembly

    Range
    6321..8312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_071470.1 hemagglutinin-neuraminidase [Newcastle disease virus B1]

    Status: PROVISIONAL

Nucleotide Protein
Heading Accession and Version

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Research Materials