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SLC16A4 solute carrier family 16 member 4 [ Homo sapiens (human) ]

Gene ID: 9122, updated on 5-Jul-2020

Summary

Official Symbol
SLC16A4provided by HGNC
Official Full Name
solute carrier family 16 member 4provided by HGNC
Primary source
HGNC:HGNC:10925
See related
Ensembl:ENSG00000168679 MIM:603878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT4; MCT5
Expression
Biased expression in kidney (RPKM 44.3), placenta (RPKM 12.3) and 10 other tissues See more
Orthologs

Genomic context

See SLC16A4 in Genome Data Viewer
Location:
1p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (110362851..110391971, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110905473..110933704, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RBM15 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 11911 Neighboring gene RNA binding motif protein 15 Neighboring gene LAMTOR5 antisense RNA 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Neighboring gene prokineticin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monocarboxylic acid transport TAS
Traceable Author Statement
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
monocarboxylate transporter 5
Names
MCT 4
MCT 5
monocarboxylate transporter 4
solute carrier family 16 (monocarboxylic acid transporters), member 4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201546.2NP_001188475.1  monocarboxylate transporter 5 isoform 2

    See identical proteins and their annotated locations for NP_001188475.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to variant 1.
    Source sequence(s)
    AI245349, AK290720, AL833619, BP345760, U59185
    Consensus CDS
    CCDS55623.1
    UniProtKB/Swiss-Prot
    O15374
    Related
    ENSP00000432495.1, ENST00000472422.6
    Conserved Domains (1) summary
    cl26868
    Location:16426
    2A0111; oxalate/formate antiporter family transporter
  2. NM_001201547.1NP_001188476.1  monocarboxylate transporter 5 isoform 3

    See identical proteins and their annotated locations for NP_001188476.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the coding region which results in the use of a downstream start codon initially in a different reading frame, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus yet matches most of the protein when it is compared to isoform 1.
    Source sequence(s)
    AI245349, AK295946, BE893159, BP345760, U59185
    Consensus CDS
    CCDS55622.1
    UniProtKB/Swiss-Prot
    O15374
    Related
    ENSP00000446087.1, ENST00000541986.5
    Conserved Domains (1) summary
    cd06174
    Location:8415
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. NM_001201548.1NP_001188477.1  monocarboxylate transporter 5 isoform 4

    See identical proteins and their annotated locations for NP_001188477.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the coding region which results in the use of a downstream start codon initially in a different reading frame, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus yet matches most of the protein when it is compared to isoform 1.
    Source sequence(s)
    AI245349, AK298539, BP345760, U59185
    Consensus CDS
    CCDS55621.1
    UniProtKB/Swiss-Prot
    O15374
    Related
    ENSP00000394790.2, ENST00000437429.6
    Conserved Domains (1) summary
    cl26868
    Location:6335
    2A0111; oxalate/formate antiporter family transporter
  4. NM_001201549.2NP_001188478.1  monocarboxylate transporter 5 isoform 5

    See identical proteins and their annotated locations for NP_001188478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate, in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to variant 1.
    Source sequence(s)
    AI245349, BC021664, BP345760, U59185
    Consensus CDS
    CCDS55624.1
    UniProtKB/Swiss-Prot
    O15374
    Related
    ENSP00000358796.4, ENST00000369781.8
    Conserved Domains (1) summary
    cl26868
    Location:16306
    2A0111; oxalate/formate antiporter family transporter
  5. NM_001319220.2NP_001306149.1  monocarboxylate transporter 5 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. The resulting isoform (6) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AI245349, AL355488, BX647948
    Conserved Domains (2) summary
    cd06174
    Location:143249
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:12244
    2A0113; monocarboxylate transporter 1
  6. NM_004696.3NP_004687.1  monocarboxylate transporter 5 isoform 1

    See identical proteins and their annotated locations for NP_004687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AI245349, AK313735, U59185
    Consensus CDS
    CCDS823.1
    UniProtKB/Swiss-Prot
    O15374
    Related
    ENSP00000358794.4, ENST00000369779.9
    Conserved Domains (2) summary
    cd06174
    Location:24477
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:27442
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    110362851..110391971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271317.5XP_005271374.1  monocarboxylate transporter 5 isoform X1

    See identical proteins and their annotated locations for XP_005271374.1

    UniProtKB/Swiss-Prot
    O15374
    Conserved Domains (2) summary
    cd06174
    Location:24477
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:27442
    MFS_1; Major Facilitator Superfamily
  2. XM_006711033.3XP_006711096.1  monocarboxylate transporter 5 isoform X2

    See identical proteins and their annotated locations for XP_006711096.1

    Conserved Domains (1) summary
    cd06174
    Location:183367
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
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