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SLC16A5 solute carrier family 16 member 5 [ Homo sapiens (human) ]

Gene ID: 9121, updated on 18-Aug-2020

Summary

Official Symbol
SLC16A5provided by HGNC
Official Full Name
solute carrier family 16 member 5provided by HGNC
Primary source
HGNC:HGNC:10926
See related
Ensembl:ENSG00000170190 MIM:603879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT5; MCT6
Summary
This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Broad expression in lung (RPKM 9.8), duodenum (RPKM 9.3) and 21 other tissues See more
Orthologs

Genomic context

See SLC16A5 in Genome Data Viewer
Location:
17q25.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75087765..75106162)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73083822..73102257)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 3986 Neighboring gene ATP synthase peripheral stalk subunit d Neighboring gene tripartite motif containing 80, pseudogene Neighboring gene armadillo repeat containing 7 Neighboring gene uncharacterized LOC107985034 Neighboring gene 5', 3'-nucleotidase, cytosolic Neighboring gene Jupiter microtubule associated homolog 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
monocarboxylate transporter 6
Names
monocarboxylate transporter 5
solute carrier family 16 (monocarboxylate transporter), member 5
solute carrier family 16 (monocarboxylic acid transporters), member 5
solute carrier family 16, member 5 (monocarboxylic acid transporter 6)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271765.2NP_001258694.1  monocarboxylate transporter 6

    See identical proteins and their annotated locations for NP_001258694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK000416, AW452009
    Consensus CDS
    CCDS11713.1
    UniProtKB/Swiss-Prot
    O15375
    Related
    ENSP00000463434.1, ENST00000580123.5
    Conserved Domains (1) summary
    TIGR00892
    Location:1453
    2A0113; monocarboxylate transporter 1
  2. NM_001369668.1NP_001356597.1  monocarboxylate transporter 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC111186, BC033611, U59299
    Related
    ENSP00000390564.2, ENST00000450736.6
    Conserved Domains (1) summary
    TIGR00892
    Location:1453
    2A0113; monocarboxylate transporter 1
  3. NM_004695.4NP_004686.1  monocarboxylate transporter 6

    See identical proteins and their annotated locations for NP_004686.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK000416, AW452009, BC009684, BC033611, BI820515
    Consensus CDS
    CCDS11713.1
    UniProtKB/Swiss-Prot
    O15375
    Related
    ENSP00000330141.4, ENST00000329783.9
    Conserved Domains (1) summary
    TIGR00892
    Location:1453
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75087765..75106162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025293.2XP_016880782.1  monocarboxylate transporter 6 isoform X4

  2. XM_005257790.1XP_005257847.1  monocarboxylate transporter 6 isoform X1

    Related
    ENSP00000440212.2, ENST00000538213.6
    Conserved Domains (2) summary
    cd06174
    Location:54452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:41493
    2A0113; monocarboxylate transporter 1
  3. XM_011525462.1XP_011523764.1  monocarboxylate transporter 6 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:72419
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:84419
    MFS_1; Major Facilitator Superfamily
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