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INA internexin neuronal intermediate filament protein alpha [ Homo sapiens (human) ]

Gene ID: 9118, updated on 5-Jan-2020

Summary

Official Symbol
INAprovided by HGNC
Official Full Name
internexin neuronal intermediate filament protein alphaprovided by HGNC
Primary source
HGNC:HGNC:6057
See related
Ensembl:ENSG00000148798 MIM:605338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEF5; NF-66; TXBP-1
Summary
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]
Expression
Biased expression in brain (RPKM 37.1) and adrenal (RPKM 7.8) See more
Orthologs

Genomic context

See INA in Genome Data Viewer
Location:
10q24.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (103277138..103290346)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105036919..105050108)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ST13, Hsp70 interacting protein pseudogene 13 Neighboring gene ribulose-5-phosphate-3-epimerase like 1 Neighboring gene polycomb group ring finger 6 Neighboring gene RNA, U11 small nuclear 3, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5935 Neighboring gene TATA-box binding protein associated factor 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify internexin neuronal intermediate filament protein alpha unit (INA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify internexin neuronal intermediate filament protein alpha unit (INA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify internexin neuronal intermediate filament protein alpha unit (INA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify internexin neuronal intermediate filament protein alpha unit (INA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18662, FLJ57501, MGC12702

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
neurofilament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
postsynaptic actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
postsynaptic intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development HEP PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
neurofilament IEA
Inferred from Electronic Annotation
more info
 
postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-internexin
Names
66 kDa neurofilament protein
alpha-Inx
neurofilament 5 (66kD)
neurofilament-66, tax-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012318.1 RefSeqGene

    Range
    4976..18184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032727.4NP_116116.1  alpha-internexin

    See identical proteins and their annotated locations for NP_116116.1

    Status: REVIEWED

    Source sequence(s)
    AL591408, BC006359
    Consensus CDS
    CCDS7545.1
    UniProtKB/Swiss-Prot
    Q16352
    Related
    ENSP00000358865.4, ENST00000369849.9
    Conserved Domains (2) summary
    pfam00038
    Location:93406
    Filament; Intermediate filament protein
    pfam04732
    Location:1092
    Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    103277138..103290346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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