Format

Send to:

Choose Destination

IGFN1 immunoglobulin like and fibronectin type III domain containing 1 [ Homo sapiens (human) ]

Gene ID: 91156, updated on 25-Jan-2022

Summary

Official Symbol
IGFN1provided by HGNC
Official Full Name
immunoglobulin like and fibronectin type III domain containing 1provided by HGNC
Primary source
HGNC:HGNC:24607
See related
Ensembl:ENSG00000163395 MIM:617309; AllianceGenome:HGNC:24607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EEF1A2BP1
Summary
Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules; retina layer formation; and synapse assembly. Predicted to be located in Z disc and nucleus. Predicted to be active in synapse. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in endometrium (RPKM 9.4), testis (RPKM 3.4) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IGFN1 in Genome Data Viewer
Location:
1q32.1
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (201190780..201228952)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201159952..201198080)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene transmembrane protein 9 Neighboring gene plakophilin 1 Neighboring gene uncharacterized LOC101929326

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434B1231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retina layer formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
immunoglobulin-like and fibronectin type III domain-containing protein 1
Names
EEF1A2-binding protein 1
KY-interacting protein 1
eEF1A2 binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164586.2NP_001158058.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001158058.1

    Status: VALIDATED

    Source sequence(s)
    AC103925
    Consensus CDS
    CCDS53455.1
    UniProtKB/Swiss-Prot
    Q86VF2
    Related
    ENSP00000334714.4, ENST00000335211.9
    Conserved Domains (5) summary
    cd00096
    Location:36333700
    Ig; Immunoglobulin domain
    smart00410
    Location:34153494
    IG_like; Immunoglobulin like
    cd00063
    Location:33023388
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:29120
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30173104
    Ig; Immunoglobulin domain
  2. NM_001367841.1NP_001354770.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC103925
    Related
    ENSP00000295591.9, ENST00000295591.12

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    201190780..201228952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245580.3XP_005245637.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X2

    Conserved Domains (5) summary
    cd00096
    Location:36083675
    Ig; Immunoglobulin domain
    smart00410
    Location:33903469
    IG_like; Immunoglobulin like
    cd00063
    Location:32773363
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:29120
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30173104
    Ig; Immunoglobulin domain
  2. XM_017002787.1XP_016858276.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X3

  3. XM_006711618.3XP_006711681.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X4

    Conserved Domains (4) summary
    cd00096
    Location:29302998
    Ig; Immunoglobulin domain
    cd00063
    Location:33023388
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:29120
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30173104
    Ig; Immunoglobulin domain
  4. XM_011510120.3XP_011508422.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011508422.1

    UniProtKB/Swiss-Prot
    Q86VF2
    Conserved Domains (5) summary
    cd00096
    Location:36333700
    Ig; Immunoglobulin domain
    smart00410
    Location:34153494
    IG_like; Immunoglobulin like
    cd00063
    Location:33023388
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:29120
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30173104
    Ig; Immunoglobulin domain
  5. XM_011510121.3XP_011508423.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011508423.1

    UniProtKB/Swiss-Prot
    Q86VF2
    Conserved Domains (5) summary
    cd00096
    Location:36333700
    Ig; Immunoglobulin domain
    smart00410
    Location:34153494
    IG_like; Immunoglobulin like
    cd00063
    Location:33023388
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:29120
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30173104
    Ig; Immunoglobulin domain

RNA

  1. XR_921994.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178275.4: Suppressed sequence

    Description
    NM_178275.4: This RefSeq was permanently suppressed because the CDS was partial.
Support Center