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ZNF682 zinc finger protein 682 [ Homo sapiens (human) ]

Gene ID: 91120, updated on 12-Oct-2019

Summary

Official Symbol
ZNF682provided by HGNC
Official Full Name
zinc finger protein 682provided by HGNC
Primary source
HGNC:HGNC:28857
See related
Ensembl:ENSG00000197124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BC39498_3
Expression
Ubiquitous expression in thyroid (RPKM 2.3), skin (RPKM 2.1) and 23 other tissues See more
Orthologs

Genomic context

See ZNF682 in Genome Data Viewer
Location:
19p12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (20004418..20039505, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (20115227..20150277, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 93 Neighboring gene BCL2 interacting protein 3 pseudogene 12 Neighboring gene vomeronasal 1 receptor 77 pseudogene Neighboring gene uncharacterized LOC105372308 Neighboring gene BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Neighboring gene uncharacterized LOC105372309 Neighboring gene BCL2 interacting protein 3 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

General gene information

Markers

Homology

Clone Names

  • FLJ90362

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077349.1NP_001070817.1  zinc finger protein 682 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate segment in the 5' UTR and coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC006539, AK098164, DB174863
    Consensus CDS
    CCDS42534.1
    UniProtKB/TrEMBL
    B3KUX2
    Related
    ENSP00000380348.1, ENST00000397162.5
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:207413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:339359
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:183207
    zf-H2C2_2; Zinc-finger double domain
  2. NM_033196.3NP_149973.1  zinc finger protein 682 isoform 1

    See identical proteins and their annotated locations for NP_149973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC006539, DA612976, DA788529, DR002650
    Consensus CDS
    CCDS42533.1
    UniProtKB/Swiss-Prot
    O95780
    Related
    ENSP00000380351.1, ENST00000397165.7
    Conserved Domains (5) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:239445
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:371391
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:215239
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    20004418..20039505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027456.1XP_016882945.1  zinc finger protein 682 isoform X2

    UniProtKB/Swiss-Prot
    O95780
    Related
    ENSP00000471717.1, ENST00000595736.1
    Conserved Domains (3) summary
    COG5048
    Location:163369
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:295315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:139163
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017027455.1XP_016882944.1  zinc finger protein 682 isoform X1

    UniProtKB/TrEMBL
    B9EG95
    Related
    ENSP00000470718.1, ENST00000597972.5
    Conserved Domains (5) summary
    smart00349
    Location:1070
    KRAB; krueppel associated box
    COG5048
    Location:245451
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1049
    KRAB; KRAB box
    pfam13465
    Location:221245
    zf-H2C2_2; Zinc-finger double domain
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