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NMI N-myc and STAT interactor [ Homo sapiens (human) ]

Gene ID: 9111, updated on 7-Jun-2020

Summary

Official Symbol
NMIprovided by HGNC
Official Full Name
N-myc and STAT interactorprovided by HGNC
Primary source
HGNC:HGNC:7854
See related
Ensembl:ENSG00000123609 MIM:603525
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 16.7), bone marrow (RPKM 15.4) and 24 other tissues See more
Orthologs

Genomic context

See NMI in Genome Data Viewer
Location:
2q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (151270465..151289668, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (152126982..152146430, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fatty acid binding protein 5 pseudogene 10 Neighboring gene RNA binding motif protein 43 Neighboring gene uncharacterized LOC107985827 Neighboring gene uncharacterized LOC101929319 Neighboring gene TNF alpha induced protein 6 Neighboring gene microRNA 4773-1 Neighboring gene microRNA 4773-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates N-myc (and STAT) interactor in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
interferon-gamma-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-alpha biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-beta biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004688.3NP_004679.2  N-myc-interactor

    See identical proteins and their annotated locations for NP_004679.2

    Status: REVIEWED

    Source sequence(s)
    BC001268, BC021987, CB151555
    Consensus CDS
    CCDS2192.1
    UniProtKB/Swiss-Prot
    Q13287
    Related
    ENSP00000243346.5, ENST00000243346.10
    Conserved Domains (3) summary
    cd12544
    Location:157237
    RRM_NMI; RNA recognition motif in N-myc-interactor (Nmi) and similar proteins
    pfam07292
    Location:203291
    NID; Nmi/IFP 35 domain (NID)
    pfam07334
    Location:29104
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    151270465..151289668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246941.2XP_005246998.1  N-myc-interactor isoform X1

    See identical proteins and their annotated locations for XP_005246998.1

    UniProtKB/Swiss-Prot
    Q13287
    Conserved Domains (3) summary
    cd12544
    Location:157237
    RRM_NMI; RNA recognition motif in N-myc-interactor (Nmi) and similar proteins
    pfam07292
    Location:203291
    NID; Nmi/IFP 35 domain (NID)
    pfam07334
    Location:29104
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
  2. XM_017005247.1XP_016860736.1  N-myc-interactor isoform X1

    UniProtKB/Swiss-Prot
    Q13287
    Conserved Domains (3) summary
    cd12544
    Location:157237
    RRM_NMI; RNA recognition motif in N-myc-interactor (Nmi) and similar proteins
    pfam07292
    Location:203291
    NID; Nmi/IFP 35 domain (NID)
    pfam07334
    Location:29104
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
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