Format

Send to:

Choose Destination

CCDC149 coiled-coil domain containing 149 [ Homo sapiens (human) ]

Gene ID: 91050, updated on 16-Oct-2021

Summary

Official Symbol
CCDC149provided by HGNC
Official Full Name
coiled-coil domain containing 149provided by HGNC
Primary source
HGNC:HGNC:25405
See related
Ensembl:ENSG00000181982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 7.3), ovary (RPKM 5.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CCDC149 in Genome Data Viewer
Location:
4p15.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (24803514..24980204, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (24807739..24981826, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 65 Neighboring gene superoxide dismutase 3 Neighboring gene uncharacterized LOC102723675 Neighboring gene leucine rich repeat LGI family member 2 Neighboring gene uncharacterized LOC105374534

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13410, DKFZp761B107

General protein information

Preferred Names
coiled-coil domain-containing protein 149

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130726.5NP_001124198.2  coiled-coil domain-containing protein 149 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC006390, AC116422
    Consensus CDS
    CCDS47036.1
    Related
    ENSP00000425715.1, ENST00000504487.5
    Conserved Domains (2) summary
    TIGR01612
    Location:146451
    235kDa-fam; reticulocyte binding/rhoptry protein
    COG1196
    Location:21263
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  2. NM_001330644.2NP_001317573.1  coiled-coil domain-containing protein 149 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC006390, AC116422, AK296454, AL545064, BQ671265, CB243678, DB500831
    UniProtKB/Swiss-Prot
    Q6ZUS6
  3. NM_001395273.1NP_001382202.1  coiled-coil domain-containing protein 149 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC006390, AC116422, AK296454, AL545064, CB243678, DB500831
    Consensus CDS
    CCDS82914.1
    Conserved Domains (1) summary
    COG1196
    Location:21276
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  4. NM_173463.6NP_775734.2  coiled-coil domain-containing protein 149 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC006390, AK302905, CB243678, DB244172
    Consensus CDS
    CCDS33967.2
    UniProtKB/Swiss-Prot
    Q6ZUS6
    Related
    ENSP00000374260.4, ENST00000389609.8
    Conserved Domains (2) summary
    pfam09789
    Location:26338
    DUF2353; Uncharacterized coiled-coil protein (DUF2353)
    cl00459
    Location:91211
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    24803514..24980204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513907.3XP_011512209.1  coiled-coil domain-containing protein 149 isoform X3

    See identical proteins and their annotated locations for XP_011512209.1

    Conserved Domains (2) summary
    pfam09789
    Location:1283
    DUF2353; Uncharacterized coiled-coil protein (DUF2353)
    cl00459
    Location:36156
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  2. XM_017008827.2XP_016864316.1  coiled-coil domain-containing protein 149 isoform X2

    UniProtKB/Swiss-Prot
    Q6ZUS6
    Conserved Domains (2) summary
    pfam09789
    Location:26338
    DUF2353; Uncharacterized coiled-coil protein (DUF2353)
    cl00459
    Location:91211
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  3. XM_011513906.3XP_011512208.1  coiled-coil domain-containing protein 149 isoform X1

    Conserved Domains (2) summary
    pfam09789
    Location:26338
    DUF2353; Uncharacterized coiled-coil protein (DUF2353)
    cl00459
    Location:91211
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  4. XM_011513908.2XP_011512210.1  coiled-coil domain-containing protein 149 isoform X3

    See identical proteins and their annotated locations for XP_011512210.1

    Conserved Domains (2) summary
    pfam09789
    Location:1283
    DUF2353; Uncharacterized coiled-coil protein (DUF2353)
    cl00459
    Location:36156
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001330643.2: Suppressed sequence

    Description
    NM_001330643.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Support Center