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FCGR2C Fc gamma receptor IIc (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 9103, updated on 23-Nov-2021

Summary

Official Symbol
FCGR2Cprovided by HGNC
Official Full Name
Fc gamma receptor IIc (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:15626
See related
MIM:612169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD32; FCG2; CD32C; CDW32; IGFR2; FCRIIC; FcgammaRIIc
Summary
This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]
Annotation information
Annotation category: suggests misassembly
Note: This gene contains a polymorphism which is well-represented in the population. One allele contains an early stop codon, making it subject to nonsense-mediated mRNA decay (NMD), and the other encodes a functioning protein. Since both alleles appear in the population (PMID:12215903), both the non-coding and coding variants are represented. [13 Feb 2013]
Expression
Biased expression in placenta (RPKM 73.0), appendix (RPKM 16.5) and 6 other tissues See more
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Genomic context

See FCGR2C in Genome Data Viewer
Location:
1q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161581339..161601220)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161551129..161571010)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Asn (anticodon GTT) 1-1 Neighboring gene Fc gamma receptor IIIa Neighboring gene tRNA-Leu (anticodon CAA) 6-1 Neighboring gene heat shock protein family A (Hsp70) member 7 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates the gene expression of FCGR2C in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgG binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
low affinity immunoglobulin gamma Fc region receptor II-c
Names
Fc fragment of IgG receptor IIc
Fc fragment of IgG, low affinity IIc, receptor for (CD32)
Fc gamma receptor IIC
IgG Fc receptor II-c
fc-gamma-RIIc
immunoglobulin G Fc receptor II-c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011982.1 RefSeqGene

    Range
    5001..24882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_201563.5NP_963857.3  low affinity immunoglobulin gamma Fc region receptor II-c precursor

    See identical proteins and their annotated locations for NP_963857.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, coding) encodes the functional protein.
    Source sequence(s)
    AL451067, DA851200, U90938
    UniProtKB/Swiss-Prot
    P31995
    Conserved Domains (3) summary
    cd05752
    Location:50128
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:132214
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:138214
    IG_like; Immunoglobulin like

RNA

  1. NR_047648.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, non-coding) represents the non-functional allele as found in the reference genome sequence.
    Source sequence(s)
    AL451067, BC137397

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161581339..161601220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001005410.2: Suppressed sequence

    Description
    NM_001005410.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_001005411.2: Suppressed sequence

    Description
    NM_001005411.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_001005412.1: Suppressed sequence

    Description
    NM_001005412.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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