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USP10 ubiquitin specific peptidase 10 [ Homo sapiens (human) ]

Gene ID: 9100, updated on 14-May-2019

Summary

Official Symbol
USP10provided by HGNC
Official Full Name
ubiquitin specific peptidase 10provided by HGNC
Primary source
HGNC:HGNC:12608
See related
Ensembl:ENSG00000103194 MIM:609818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBPO
Summary
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in placenta (RPKM 15.2), lymph node (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See USP10 in Genome Data Viewer
Location:
16q24.1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (84699949..84779922)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (84733555..84813528)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene coactosin like F-actin binding protein 1 Neighboring gene uncharacterized LOC105371376 Neighboring gene kelch like family member 36 Neighboring gene uncharacterized LOC105371378 Neighboring gene cysteine rich secretory protein LCCL domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog

Pathways from BioSystems

  • DNA Damage Bypass, organism-specific biosystem (from REACTOME)
    DNA Damage Bypass, organism-specific biosystemIn addition to various processes for removing lesions from the DNA, cells have developed specific mechanisms for tolerating unrepaired damage during the replication of the genome. These mechanisms ar...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Termination of translesion DNA synthesis, organism-specific biosystem (from REACTOME)
    Termination of translesion DNA synthesis, organism-specific biosystemThe initiation and extent of translesion DNA synthesis (TLS) has to be tightly controlled in order to limit TLS-induced mutagenesis, caused by the low fidelity of TLS-participating DNA polymerases. S...
  • Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, organism-specific biosystem (from REACTOME)
    Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, organism-specific biosystemUbiquitous environmental and endogenous genotoxic agents cause DNA lesions that can interfere with normal DNA metabolism including DNA replication, eventually resulting in mutations that lead to carc...
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2621, KIAA0190

Gene Ontology Provided by GOA

Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
translesion synthesis TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 10
Names
deubiquitinating enzyme 10
ubiquitin specific protease 10
ubiquitin thioesterase 10
ubiquitin thiolesterase 10
ubiquitin-specific-processing protease 10
NP_001259004.1
NP_005144.2
XP_006721395.1
XP_011521745.1
XP_016879352.1
XP_016879353.1
XP_016879354.1
XP_016879355.1
XP_016879356.1
XP_016879357.1
XP_016879358.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272075.1NP_001259004.1  ubiquitin carboxyl-terminal hydrolase 10 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK299618, D80012, DB077919, GD151792
    Consensus CDS
    CCDS62004.1
    UniProtKB/Swiss-Prot
    Q14694
    Related
    ENSP00000457411.1, ENST00000570191.5
    Conserved Domains (2) summary
    cd02257
    Location:524797
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:418796
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. NM_005153.2NP_005144.2  ubiquitin carboxyl-terminal hydrolase 10 isoform 2

    See identical proteins and their annotated locations for NP_005144.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC009116, BC000263, BX537402, DB077919
    Consensus CDS
    CCDS45537.1
    UniProtKB/Swiss-Prot
    Q14694
    Related
    ENSP00000219473.7, ENST00000219473.11
    Conserved Domains (2) summary
    cd02257
    Location:520793
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:414792
    UCH; Ubiquitin carboxyl-terminal hydrolase

RNA

  1. NR_073577.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK293304, D80012, DB077919, GD151792
  2. NR_073578.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks four alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of two upstream ORFs that are predicted to interfere with translation of the longest ORF; translation of either of the upstream ORFs renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CR749515, D80012, DB077919, GD151792
    Related
    ENST00000540269.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    84699949..84779922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023869.1XP_016879358.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

    Conserved Domains (2) summary
    cd02257
    Location:324597
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:218596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. XM_017023864.1XP_016879353.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

    Conserved Domains (2) summary
    cd02257
    Location:324597
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:218596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  3. XM_017023868.1XP_016879357.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

    Conserved Domains (2) summary
    cd02257
    Location:324597
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:218596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  4. XM_011523443.1XP_011521745.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

    See identical proteins and their annotated locations for XP_011521745.1

    Conserved Domains (2) summary
    cd02257
    Location:324597
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:218596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  5. XM_017023863.1XP_016879352.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

    Conserved Domains (2) summary
    cd02257
    Location:324597
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:218596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  6. XM_006721332.1XP_006721395.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

    See identical proteins and their annotated locations for XP_006721395.1

    Conserved Domains (2) summary
    cd02257
    Location:324597
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:218596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  7. XM_017023867.1XP_016879356.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

    Conserved Domains (2) summary
    cd02257
    Location:324597
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:218596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  8. XM_017023865.1XP_016879354.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

    Conserved Domains (2) summary
    cd02257
    Location:324597
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:218596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  9. XM_017023866.2XP_016879355.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

    Conserved Domains (2) summary
    cd02257
    Location:324597
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:218596
    UCH; Ubiquitin carboxyl-terminal hydrolase
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