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KIFC2 kinesin family member C2 [ Homo sapiens (human) ]

Gene ID: 90990, updated on 12-Aug-2022

Summary

Official Symbol
KIFC2provided by HGNC
Official Full Name
kinesin family member C2provided by HGNC
Primary source
HGNC:HGNC:29530
See related
Ensembl:ENSG00000167702 MIM:615216; AllianceGenome:HGNC:29530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to be involved in microtubule-based movement and mitotic spindle assembly. Predicted to be located in cytoplasm. Predicted to be part of kinesin complex. Predicted to be active in microtubule cytoskeleton and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in skin (RPKM 26.6), brain (RPKM 13.3) and 21 other tissues See more
Orthologs
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Genomic context

See KIFC2 in Genome Data Viewer
Location:
8q24.3
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144466049..144474202)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145636078..145643942)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145691720..145699585)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene LOC84773-CYHR1 readthrough Neighboring gene zinc finger TRAF-type containing 1 Neighboring gene microRNA 10400 Neighboring gene transmembrane protein 276 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1 regulatory subunit 16A Neighboring gene uncharacterized LOC101928953 Neighboring gene Sharpr-MPRA regulatory region 2015 Neighboring gene glutamic--pyruvic transaminase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369769.2NP_001356698.1  kinesin-like protein KIFC2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC084125, BC017311, BM751216, HY134032
    UniProtKB/TrEMBL
    A0A2R8YEU8
    Related
    ENSP00000494595.1, ENST00000645548.2
    Conserved Domains (1) summary
    cl22853
    Location:407732
    Motor_domain; Myosin and Kinesin motor domain
  2. NM_145754.5NP_665697.1  kinesin-like protein KIFC2 isoform 1

    See identical proteins and their annotated locations for NP_665697.1

    Status: VALIDATED

    Source sequence(s)
    AC084125, BC017311, BM751216, HY134032
    Consensus CDS
    CCDS6427.1
    UniProtKB/Swiss-Prot
    Q96AC6, Q96NN6
    Related
    ENSP00000301332.2, ENST00000301332.3
    Conserved Domains (2) summary
    smart00129
    Location:409707
    KISc; Kinesin motor, catalytic domain. ATPase
    cl22853
    Location:407707
    Motor_domain; Myosin and Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144466049..144474202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422406.1XP_047278362.1  kinesin-like protein KIFC2 isoform X1

  2. XM_047422405.1XP_047278361.1  kinesin-like protein KIFC2 isoform X1

  3. XM_011517362.3XP_011515664.1  kinesin-like protein KIFC2 isoform X2

    Conserved Domains (1) summary
    cl22853
    Location:407460
    Motor_domain; Myosin and Kinesin motor domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145636078..145643942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)