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ZNF251 zinc finger protein 251 [ Homo sapiens (human) ]

Gene ID: 90987, updated on 25-Jan-2022

Summary

Official Symbol
ZNF251provided by HGNC
Official Full Name
zinc finger protein 251provided by HGNC
Primary source
HGNC:HGNC:13045
See related
Ensembl:ENSG00000198169 AllianceGenome:HGNC:13045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic stem cell homeostasis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in endometrium (RPKM 6.9), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF251 in Genome Data Viewer
Location:
8q24.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144720909..144755603, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145946294..145980916, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 39 Neighboring gene Sharpr-MPRA regulatory region 12231 Neighboring gene uncharacterized LOC100996662 Neighboring gene uncharacterized LOC107986986 Neighboring gene uncharacterized LOC105375805 Neighboring gene Sharpr-MPRA regulatory region 4846 Neighboring gene RNA, 7SL, cytoplasmic 395, pseudogene Neighboring gene zinc finger protein 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34319

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in hematopoietic stem cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138367.2NP_612376.1  zinc finger protein 251

    See identical proteins and their annotated locations for NP_612376.1

    Status: VALIDATED

    Source sequence(s)
    AK000435, BC006258, BU674002, BX509447, DA775010, DA811573
    Consensus CDS
    CCDS47944.1
    UniProtKB/Swiss-Prot
    Q9BRH9
    Related
    ENSP00000292562.7, ENST00000292562.12
    Conserved Domains (3) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
    COG5048
    Location:207635
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435455
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144720909..144755603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447324.1XP_024303092.1  zinc finger protein 251 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
    COG5048
    Location:207635
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435455
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_005272356.4XP_005272413.1  zinc finger protein 251 isoform X4

    See identical proteins and their annotated locations for XP_005272413.1

    Conserved Domains (2) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
    pfam01352
    Location:1554
    KRAB; KRAB box
  3. XM_006716683.3XP_006716746.1  zinc finger protein 251 isoform X3

    See identical proteins and their annotated locations for XP_006716746.1

    Conserved Domains (2) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
    pfam01352
    Location:1554
    KRAB; KRAB box
  4. XM_011517361.2XP_011515663.1  zinc finger protein 251 isoform X2

    Conserved Domains (2) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
    pfam01352
    Location:1554
    KRAB; KRAB box

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187569.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    95392..130014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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