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PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 [ Homo sapiens (human) ]

Gene ID: 9088, updated on 7-Jun-2020

Summary

Official Symbol
PKMYT1provided by HGNC
Official Full Name
protein kinase, membrane associated tyrosine/threonine 1provided by HGNC
Primary source
HGNC:HGNC:29650
See related
Ensembl:ENSG00000127564 MIM:602474
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYT1; PPP1R126
Summary
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Expression
Broad expression in testis (RPKM 14.8), bone marrow (RPKM 10.4) and 16 other tissues See more
Orthologs

Genomic context

See PKMYT1 in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2972808..2980494, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3018101..3030540, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene uncharacterized LOC105371055 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene progestin and adipoQ receptor family member 4 Neighboring gene long intergenic non-protein coding RNA 514 Neighboring gene uncharacterized LOC101929613

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20093, DKFZp547K1610

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity TAS
Traceable Author Statement
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Names
myt1 kinase
protein phosphatase 1, regulatory subunit 126
NP_001245379.1
NP_001245380.1
NP_004194.3
NP_872629.1
XP_011521036.1
XP_011521037.1
XP_011521038.1
XP_024306258.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258450.2NP_001245379.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3

    See identical proteins and their annotated locations for NP_001245379.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK301926, BQ017689, DB111506
    Consensus CDS
    CCDS58415.1
    UniProtKB/Swiss-Prot
    Q99640
    Related
    ENSP00000460868.1, ENST00000574730.5
    Conserved Domains (2) summary
    smart00220
    Location:41288
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:39288
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  2. NM_001258451.2NP_001245380.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 4

    See identical proteins and their annotated locations for NP_001245380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK097642, AK301926, BQ017689, DB111506
    Consensus CDS
    CCDS58414.1
    UniProtKB/Swiss-Prot
    Q99640
    Related
    ENSP00000458943.1, ENST00000574385.5
    Conserved Domains (2) summary
    smart00220
    Location:101348
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  3. NM_004203.5NP_004194.3  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1

    See identical proteins and their annotated locations for NP_004194.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC121161, BQ017689, DB009060
    Consensus CDS
    CCDS10486.1
    UniProtKB/Swiss-Prot
    Q99640
    UniProtKB/TrEMBL
    Q0IJ49
    Related
    ENSP00000262300.8, ENST00000262300.13
    Conserved Domains (1) summary
    cd14050
    Location:108357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  4. NM_182687.3NP_872629.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 2

    See identical proteins and their annotated locations for NP_872629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK098452, BQ017689, DB009060
    Consensus CDS
    CCDS45391.1
    UniProtKB/Swiss-Prot
    Q99640
    Related
    ENSP00000397739.2, ENST00000440027.6
    Conserved Domains (2) summary
    smart00220
    Location:110357
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:108357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2972808..2980494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450490.1XP_024306258.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

    Conserved Domains (1) summary
    cd14050
    Location:108357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  2. XM_011522735.3XP_011521037.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    See identical proteins and their annotated locations for XP_011521037.1

    UniProtKB/Swiss-Prot
    Q99640
    Related
    ENSP00000459123.1, ENST00000573944.5
    Conserved Domains (2) summary
    smart00220
    Location:101348
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  3. XM_011522734.3XP_011521036.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

    See identical proteins and their annotated locations for XP_011521036.1

    UniProtKB/Swiss-Prot
    Q99640
    Conserved Domains (1) summary
    cd14050
    Location:108357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  4. XM_011522736.3XP_011521038.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    See identical proteins and their annotated locations for XP_011521038.1

    UniProtKB/Swiss-Prot
    Q99640
    Related
    ENSP00000371675.5, ENST00000382240.9
    Conserved Domains (2) summary
    smart00220
    Location:101348
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
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