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PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 [ Homo sapiens (human) ]

Gene ID: 9088, updated on 17-Jun-2019

Summary

Official Symbol
PKMYT1provided by HGNC
Official Full Name
protein kinase, membrane associated tyrosine/threonine 1provided by HGNC
Primary source
HGNC:HGNC:29650
See related
Ensembl:ENSG00000127564 MIM:602474
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYT1; PPP1R126
Summary
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Expression
Broad expression in testis (RPKM 14.8), bone marrow (RPKM 10.4) and 16 other tissues See more
Orthologs

Genomic context

See PKMYT1 in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2972808..2980494, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3018101..3030540, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene uncharacterized LOC105371055 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene progestin and adipoQ receptor family member 4 Neighboring gene long intergenic non-protein coding RNA 514 Neighboring gene uncharacterized LOC101929613

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from WikiPathways)
    Cell Cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
    Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cyclin A/B1 associated events during G2/M transition, organism-specific biosystem (from REACTOME)
    Cyclin A/B1 associated events during G2/M transition, organism-specific biosystemCell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions. The G2/M transition is regulated through the phosphorylation of nuclear lamins and h...
  • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
    G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
  • G2/M DNA replication checkpoint, organism-specific biosystem (from REACTOME)
    G2/M DNA replication checkpoint, organism-specific biosystemThe G2/M DNA replication checkpoint ensures that mitosis is not initiated until DNA replication is complete. If replication is blocked, the DNA replication checkpoint signals to maintain Cyclin B - C...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Oocyte meiosis, organism-specific biosystem (from KEGG)
    Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oocyte meiosis, conserved biosystem (from KEGG)
    Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Polo-like kinase mediated events, organism-specific biosystem (from REACTOME)
    Polo-like kinase mediated events, organism-specific biosystemAt mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A (Watanabe et al. 2004). Plk1 also phosphorylates and inhibits Myt1 activit...
  • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20093, DKFZp547K1610

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity TAS
Traceable Author Statement
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Names
myt1 kinase
protein phosphatase 1, regulatory subunit 126
NP_001245379.1
NP_001245380.1
NP_004194.3
NP_872629.1
XP_011521036.1
XP_011521037.1
XP_011521038.1
XP_024306258.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258450.2NP_001245379.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3

    See identical proteins and their annotated locations for NP_001245379.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK301926, BQ017689, DB111506
    Consensus CDS
    CCDS58415.1
    UniProtKB/Swiss-Prot
    Q99640
    Related
    ENSP00000460868.1, ENST00000574730.5
    Conserved Domains (2) summary
    smart00220
    Location:41288
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:39288
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  2. NM_001258451.2NP_001245380.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 4

    See identical proteins and their annotated locations for NP_001245380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK097642, AK301926, BQ017689, DB111506
    Consensus CDS
    CCDS58414.1
    UniProtKB/Swiss-Prot
    Q99640
    Related
    ENSP00000458943.1, ENST00000574385.5
    Conserved Domains (2) summary
    smart00220
    Location:101348
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  3. NM_004203.5NP_004194.3  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1

    See identical proteins and their annotated locations for NP_004194.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC121161, BQ017689, DB009060
    Consensus CDS
    CCDS10486.1
    UniProtKB/Swiss-Prot
    Q99640
    UniProtKB/TrEMBL
    Q0IJ49
    Related
    ENSP00000262300.8, ENST00000262300.13
    Conserved Domains (1) summary
    cd14050
    Location:108357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  4. NM_182687.3NP_872629.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 2

    See identical proteins and their annotated locations for NP_872629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK098452, BQ017689, DB009060
    Consensus CDS
    CCDS45391.1
    UniProtKB/Swiss-Prot
    Q99640
    Related
    ENSP00000397739.2, ENST00000440027.6
    Conserved Domains (2) summary
    smart00220
    Location:110357
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:108357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2972808..2980494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450490.1XP_024306258.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

    Conserved Domains (1) summary
    cd14050
    Location:108357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  2. XM_011522735.3XP_011521037.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    See identical proteins and their annotated locations for XP_011521037.1

    UniProtKB/Swiss-Prot
    Q99640
    Related
    ENSP00000459123.1, ENST00000573944.5
    Conserved Domains (2) summary
    smart00220
    Location:101348
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  3. XM_011522734.3XP_011521036.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

    See identical proteins and their annotated locations for XP_011521036.1

    UniProtKB/Swiss-Prot
    Q99640
    Conserved Domains (1) summary
    cd14050
    Location:108357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
  4. XM_011522736.3XP_011521038.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    See identical proteins and their annotated locations for XP_011521038.1

    UniProtKB/Swiss-Prot
    Q99640
    Related
    ENSP00000371675.5, ENST00000382240.9
    Conserved Domains (2) summary
    smart00220
    Location:101348
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
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