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IL33 interleukin 33 [ Homo sapiens (human) ]

Gene ID: 90865, updated on 12-Aug-2018

Summary

Official Symbol
IL33provided by HGNC
Official Full Name
interleukin 33provided by HGNC
Primary source
HGNC:HGNC:16028
See related
Ensembl:ENSG00000137033 MIM:608678; Vega:OTTHUMG00000019516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
Summary
The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in urinary bladder (RPKM 34.7), lung (RPKM 27.3) and 23 other tissues See more
Orthologs

Genomic context

See IL33 in Genome Data Viewer
Location:
9p24.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (6214591..6257983)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (6215149..6257983)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RAN binding protein 6 Neighboring gene general transcription factor IIIA pseudogene 1 Neighboring gene uncharacterized LOC107987046 Neighboring gene selenoprotein T pseudogene 1 Neighboring gene TPD52 like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
NHGRI GWA Catalog
A large-scale, consortium-based genomewide association study of asthma.
NHGRI GWA Catalog
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
NHGRI GWA Catalog
Genome-wide association study link novel loci to endometriosis.
NHGRI GWA Catalog
Genome-wide association study of periodontal pathogen colonization.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
In vitro infection with HIV-1 subtype B upregulates IL-33 expression in primary human astrocytes and SKNMC cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
    Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
  • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
    Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Development and heterogeneity of the ILC family, organism-specific biosystem (from WikiPathways)
    Development and heterogeneity of the ILC family, organism-specific biosystemDevelopment and heterogeneity of the ILC family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription f...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586H0523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-33-mediated signaling pathway TAS
Traceable Author Statement
more info
 
microglial cell activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
microglial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of immunoglobulin secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of immunoglobulin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of type 2 immune response IEA
Inferred from Electronic Annotation
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-33
Names
DVS27-related protein
interleukin-1 family member 11
nuclear factor for high endothelial venules
nuclear factor from high endothelial venules

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047209.1 RefSeqGene

    Range
    5001..47835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199640.1NP_001186569.1  interleukin-33 isoform b

    See identical proteins and their annotated locations for NP_001186569.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as 2) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB024518, AI610794, AK303943, BC047085, DB477860
    Consensus CDS
    CCDS56563.1
    UniProtKB/Swiss-Prot
    O95760
    Related
    ENSP00000414238.2, ENST00000456383.3
    Conserved Domains (1) summary
    pfam15095
    Location:5226
    IL33; Interleukin 33
  2. NM_001199641.1NP_001186570.1  interleukin-33 isoform c

    See identical proteins and their annotated locations for NP_001186570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c, also known as 3) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB024518, AI610794, AK295908, BC047085, DB477860
    Consensus CDS
    CCDS56564.1
    UniProtKB/Swiss-Prot
    O95760
    Related
    ENSP00000394039.2, ENST00000417746.6
    Conserved Domains (1) summary
    pfam15095
    Location:31142
    IL33; Interleukin 33
  3. NM_001314044.1NP_001300973.1  interleukin-33 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AB024518, AI610794, DA713547
    Consensus CDS
    CCDS6468.1
    UniProtKB/Swiss-Prot
    O95760
    Related
    ENSP00000370842.3, OTTHUMP00000021041, ENST00000381434.7, OTTHUMT00000051655
    Conserved Domains (1) summary
    pfam15095
    Location:5268
    IL33; Interleukin 33
  4. NM_001314045.1NP_001300974.1  interleukin-33 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AB024518, AI610794, DA439244
    Consensus CDS
    CCDS6468.1
    UniProtKB/Swiss-Prot
    O95760
    Conserved Domains (1) summary
    pfam15095
    Location:5268
    IL33; Interleukin 33
  5. NM_001314046.1NP_001300975.1  interleukin-33 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a. Variants 6 and 7 both encode the same isoform (d).
    Source sequence(s)
    AB024518, AI610794, DB199599, DB266668
    UniProtKB/Swiss-Prot
    O95760
    Conserved Domains (1) summary
    pfam15095
    Location:5262
    IL33; Interleukin 33
  6. NM_001314047.1NP_001300976.1  interleukin-33 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a. Variants 6 and 7 both encode the same isoform (d).
    Source sequence(s)
    AB024518, AI610794, DA713547, DA719342
    UniProtKB/Swiss-Prot
    O95760
    Conserved Domains (1) summary
    pfam15095
    Location:5262
    IL33; Interleukin 33
  7. NM_001314048.1NP_001300977.1  interleukin-33 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB024518, AI610794, DB199599, HQ641439
    Consensus CDS
    CCDS83341.1
    UniProtKB/Swiss-Prot
    O95760
    Related
    ENSP00000478858.1, ENST00000611532.4
    Conserved Domains (1) summary
    pfam15095
    Location:5226
    IL33; Interleukin 33
  8. NM_001353802.1NP_001340731.1  interleukin-33 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The promoter and 5' terminal exon sequence is from an endogenous retroviral LTR (PMID: 28715472). The resulting isoform (f),has a distinct N-terminus and is shorter than isoform 1. The encoded protein is expressed in a subset of colon cancer cells.
    Source sequence(s)
    AL353741
    Conserved Domains (1) summary
    pfam15095
    Location:1227
    IL33; Interleukin 33
  9. NM_033439.3NP_254274.1  interleukin-33 isoform a precursor

    See identical proteins and their annotated locations for NP_254274.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as 1). Variants 1, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AB024518, AI610794, BC047085, DB477860
    Consensus CDS
    CCDS6468.1
    UniProtKB/Swiss-Prot
    O95760
    Conserved Domains (1) summary
    pfam15095
    Location:5268
    IL33; Interleukin 33

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    6214591..6257983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015285.1XP_016870774.1  interleukin-33 isoform X1

    Conserved Domains (1) summary
    pfam15095
    Location:5262
    IL33; Interleukin 33
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