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SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 [ Homo sapiens (human) ]

Gene ID: 90864, updated on 5-Aug-2022

Summary

Official Symbol
SPSB3provided by HGNC
Official Full Name
splA/ryanodine receptor domain and SOCS box containing 3provided by HGNC
Primary source
HGNC:HGNC:30629
See related
Ensembl:ENSG00000162032 MIM:611659; AllianceGenome:HGNC:30629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSB3; C16orf31
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 23.4), spleen (RPKM 22.6) and 25 other tissues See more
Orthologs
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Genomic context

See SPSB3 in Genome Data Viewer
Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1776712..1782571, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1792547..1798407, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1826713..1832572, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene NUBP iron-sulfur cluster assembly factor 2, cytosolic Neighboring gene insulin like growth factor binding protein acid labile subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
SPRY domain-containing SOCS box protein 3
Names
SPRY domain-containing SOCS box protein SSB-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324081.1NP_001311010.1  SPRY domain-containing SOCS box protein 3

    Status: VALIDATED

    Source sequence(s)
    AC012180
    Consensus CDS
    CCDS32365.1
    UniProtKB/Swiss-Prot
    Q6PJ21, Q96RY2
    Related
    ENSP00000301717.4, ENST00000301717.8
    Conserved Domains (2) summary
    cd03717
    Location:273312
    SOCS_SOCS_like; SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to ...
    cd12876
    Location:104286
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
  2. NM_080861.4NP_543137.2  SPRY domain-containing SOCS box protein 3

    See identical proteins and their annotated locations for NP_543137.2

    Status: VALIDATED

    Source sequence(s)
    AK074190, BI768095, BM836743
    Consensus CDS
    CCDS32365.1
    UniProtKB/Swiss-Prot
    Q6PJ21, Q96RY2
    Related
    ENSP00000457206.1, ENST00000566339.6
    Conserved Domains (2) summary
    cd03717
    Location:273312
    SOCS_SOCS_like; SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to ...
    cd12876
    Location:104286
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1776712..1782571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255673.6XP_005255730.1  SPRY domain-containing SOCS box protein 3 isoform X1

    Conserved Domains (2) summary
    cd03717
    Location:328367
    SOCS_SOCS_like; SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to ...
    cd12876
    Location:159341
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
  2. XM_047434866.1XP_047290822.1  SPRY domain-containing SOCS box protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q96RY2
    Related
    ENST00000564709.5
  3. XM_047434867.1XP_047290823.1  SPRY domain-containing SOCS box protein 3 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    1792547..1798407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)