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JPT2 Jupiter microtubule associated homolog 2 [ Homo sapiens (human) ]

Gene ID: 90861, updated on 3-May-2025
Official Symbol
JPT2provided by HGNC
Official Full Name
Jupiter microtubule associated homolog 2provided by HGNC
Primary source
HGNC:HGNC:14137
See related
Ensembl:ENSG00000206053 MIM:619241; AllianceGenome:HGNC:14137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L11; HN1L; C16orf34
Summary
Involved in endocytosis involved in viral entry into host cell and regulation of calcium-mediated signaling. Located in cytosol; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in prostate (RPKM 16.7), placenta (RPKM 16.5) and 25 other tissues See more
Orthologs
mouse all
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See JPT2 in Genome Data Viewer
Location:
16p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1678279..1702086)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1694127..1717934)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1728280..1752087)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 140 Neighboring gene uncharacterized LOC105371046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1662256-1662756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1662757-1663257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10230 Neighboring gene cramped chromatin regulator homolog 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1696049-1696268 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1701290-1701464 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1728137-1728772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1739823-1740519 Neighboring gene Sharpr-MPRA regulatory region 11614 Neighboring gene Sharpr-MPRA regulatory region 3989 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1755527-1756391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6999 Neighboring gene MAPK8IP3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10232 Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1784965-1785466 Neighboring gene microRNA 3177

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion. Chen X, et al. Adv Sci (Weinh), 2024 Apr. PMID 38417123, Free PMC Article
  2. Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling. Gunaratne GS, et al. Sci Signal, 2021 Mar 23. PMID 33758061, Free PMC Article
  3. HN1L promotes invasion and metastasis of the esophagogastric junction adenocarcinoma. Wang ZY, et al. Thorac Cancer, 2021 Mar. PMID 33471419, Free PMC Article
  4. HN1L-mediated transcriptional axis AP-2γ/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma. Li L, et al. Cell Death Differ, 2019 Nov. PMID 30778199, Free PMC Article
  5. Overexpression of HN1L promotes cell malignant proliferation in non-small cell lung cancer. Li L, et al. Cancer Biol Ther, 2017 Nov 2. PMID 29053395, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion.
    Title: JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion.
  2. Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12.
    Title: Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12.
  3. HN1L/AP-2gamma/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.
    Title: HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.
  4. HN1L promotes stem cell-like properties by regulating TGF-beta signaling pathway through targeting FOXP2 in prostate cancer.
    Title: HN1L promotes stem cell-like properties by regulating TGF-β signaling pathway through targeting FOXP2 in prostate cancer.
  5. HN1L/JPT2: A signaling protein that connects NAADP generation to Ca(2+) microdomain formation.
    Title: HN1L/JPT2: A signaling protein that connects NAADP generation to Ca(2+) microdomain formation.
  6. HN1L promotes invasion and metastasis of the esophagogastric junction adenocarcinoma.
    Title: HN1L promotes invasion and metastasis of the esophagogastric junction adenocarcinoma.
  7. HN1L promotes migration and invasion of breast cancer by up-regulating the expression of HMGB1.
    Title: HN1L promotes migration and invasion of breast cancer by up-regulating the expression of HMGB1.
  8. Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling.
    Title: Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling.
  9. HN1L-mediated transcriptional axis AP-2gamma/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma.
    Title: HN1L-mediated transcriptional axis AP-2γ/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma.
  10. reveal that breast cancer stem cell (BCSC) in triple-negative breast cancer depend on the transcription regulator HN1L for the sustained activation of the LEPR-STAT3 pathway, which makes it a potentially important target for both prognosis and BCSC therapy.
    Title: HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: CRAMP1

Homology

Clone Names

  • FLJ13092, KIAA1426

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis involved in viral entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
Preferred Names
jupiter microtubule associated homolog 2
Names
CRAMP_1 like
HN1 like
HN1-like protein
hematological and neurological expressed 1 like
hematological and neurological expressed 1-like protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001434664.1 → NP_001421593.1  jupiter microtubule associated homolog 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL031009, AL031710
    UniProtKB/TrEMBL
    H3BMV3

  2. NM_001434665.1 → NP_001421594.1  jupiter microtubule associated homolog 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL031009, AL031710

  3. NM_001434666.1 → NP_001421595.1  jupiter microtubule associated homolog 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL031009, AL031710
    UniProtKB/TrEMBL
    H3BMV3

  4. NM_001434667.1 → NP_001421596.1  jupiter microtubule associated homolog 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL031009, AL031710
    UniProtKB/TrEMBL
    A6NGP5, B4E1X8, H3BU16

  5. NM_001434668.1 → NP_001421597.1  jupiter microtubule associated homolog 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL031009, AL031710

  6. NM_144570.3 → NP_653171.1  jupiter microtubule associated homolog 2 isoform 4

    See identical proteins and their annotated locations for NP_653171.1

    Status: VALIDATED

    Source sequence(s)
    AK023154, AL031710, BC060853, BM474060, BM837125
    Consensus CDS
    CCDS10441.1
    UniProtKB/Swiss-Prot
    B1AJY2, B4DLH4, Q6EIC7, Q9H910
    UniProtKB/TrEMBL
    H3BU16
    Related
    ENSP00000248098.3, ENST00000248098.8
    Conserved Domains (1) summary
    pfam17054
    Location:10 → 48
    JUPITER; Microtubule-Associated protein Jupiter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1678279..1702086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    1694127..1717934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H910.1 GenPept UniProtKB/Swiss-Prot:Q9H910

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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