Format

Send to:

Choose Destination

EIF1AY eukaryotic translation initiation factor 1A Y-linked [ Homo sapiens (human) ]

Gene ID: 9086, updated on 9-Dec-2018

Summary

Official Symbol
EIF1AYprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 1A Y-linkedprovided by HGNC
Primary source
HGNC:HGNC:3252
See related
Ensembl:ENSG00000198692 MIM:400014
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eIF-4C
Summary
This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in bone marrow (RPKM 13.9), prostate (RPKM 13.1) and 20 other tissues See more

Genomic context

See EIF1AY in Genome Data Viewer
Location:
Yq11.223
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) Y NC_000024.10 (20575711..20593154)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (22737597..22755040)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis-specific transcript, Y-linked 10 Neighboring gene lysine demethylase 5D pseudogene 1 Neighboring gene family with sequence similarity 8, member A1 pseudogene Neighboring gene transducin beta like 1 Y-linked pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Translation Factors, organism-specific biosystem (from WikiPathways)
    Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45762

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
translational initiation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 1A, Y-chromosomal
Names
eIF-1A Y isoform
eukaryotic translation initiation factor 1A, Y chromosome
eukaryotic translation initiation factor 4C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278612.1NP_001265541.1  eukaryotic translation initiation factor 1A, Y-chromosomal isoform 2

    See identical proteins and their annotated locations for NP_001265541.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC007678, AF000987, BG499107, BP331805, DQ786267
    Consensus CDS
    CCDS65368.1
    UniProtKB/Swiss-Prot
    O14602
    UniProtKB/TrEMBL
    A6NJH9
    Related
    ENSP00000372222.3, ENST00000382772.3
    Conserved Domains (1) summary
    cl09927
    Location:1114
    S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
  2. NM_004681.4NP_004672.2  eukaryotic translation initiation factor 1A, Y-chromosomal isoform 1

    See identical proteins and their annotated locations for NP_004672.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007678, AF000987, BC005248, BG499107
    Consensus CDS
    CCDS14795.1
    UniProtKB/Swiss-Prot
    O14602
    Related
    ENSP00000354722.2, ENST00000361365.6
    Conserved Domains (1) summary
    PTZ00329
    Location:1131
    PTZ00329; eukaryotic translation initiation factor 1A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p12 Primary Assembly

    Range
    20575711..20593154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center