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TCEAL8 transcription elongation factor A like 8 [ Homo sapiens (human) ]

Gene ID: 90843, updated on 1-Aug-2020

Summary

Official Symbol
TCEAL8provided by HGNC
Official Full Name
transcription elongation factor A like 8provided by HGNC
Primary source
HGNC:HGNC:28683
See related
Ensembl:ENSG00000180964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WEX3
Summary
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 33.7), urinary bladder (RPKM 29.7) and 25 other tissues See more
Orthologs

Genomic context

See TCEAL8 in Genome Data Viewer
Location:
Xq22.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (103252995..103255193, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102507923..102510121, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chrX.1665 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1666 Neighboring gene guanosine monophosphate reductase pseudogene Neighboring gene transcription elongation factor A like 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45400

Gene Ontology Provided by GOA

Function Evidence Code Pubs
WW domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription elongation factor A protein-like 8
Names
TCEA-like protein 8
transcription elongation factor A (SII)-like 8
transcription elongation factor S-II protein-like 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016256.1 RefSeqGene

    Range
    5039..7199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006684.1NP_001006685.1  transcription elongation factor A protein-like 8

    See identical proteins and their annotated locations for NP_001006685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK026349, BC035573, BU932815
    Consensus CDS
    CCDS14504.1
    UniProtKB/Swiss-Prot
    Q8IYN2
    Related
    ENSP00000353093.4, ENST00000360000.8
    Conserved Domains (1) summary
    pfam04538
    Location:1110
    BEX; Brain expressed X-linked like family
  2. NM_153333.3NP_699164.1  transcription elongation factor A protein-like 8

    See identical proteins and their annotated locations for NP_699164.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK026349, BC035573, BU932815
    Consensus CDS
    CCDS14504.1
    UniProtKB/Swiss-Prot
    Q8IYN2
    Related
    ENSP00000361770.3, ENST00000372685.8
    Conserved Domains (1) summary
    pfam04538
    Location:1110
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    103252995..103255193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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