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PRMT9 protein arginine methyltransferase 9 [ Homo sapiens (human) ]

Gene ID: 90826, updated on 12-Oct-2019

Summary

Official Symbol
PRMT9provided by HGNC
Official Full Name
protein arginine methyltransferase 9provided by HGNC
Primary source
HGNC:HGNC:25099
See related
Ensembl:ENSG00000164169 MIM:616125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRMT10
Summary
This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in adrenal (RPKM 9.7), thyroid (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See PRMT9 in Genome Data Viewer
Location:
4q31.23
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (147635650..147684230, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (148558936..148605381, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377478 Neighboring gene long intergenic non-protein coding RNA 2507 Neighboring gene transmembrane protein 184C Neighboring gene Rho GTPase activating protein 10 Neighboring gene RNA, 5S ribosomal pseudogene 165 Neighboring gene microRNA 4799

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46629

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-arginine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-arginine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-arginine omega-N symmetric methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
mRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-arginine methylation, to symmetrical-dimethyl arginine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein arginine N-methyltransferase 9
Names
protein arginine N-methyltransferase 10
protein arginine methyltransferase 10 (putative)
putative protein arginine N-methyltransferase 10
putative protein arginine N-methyltransferase 9
NP_001291387.1
NP_001337070.1
NP_001337071.1
NP_001337072.1
NP_001337073.1
NP_612373.2
XP_016864312.1
XP_016864313.1
XP_016864314.1
XP_016864315.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053105.1 RefSeqGene

    Range
    5068..51446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001304458.1NP_001291387.1  protein arginine N-methyltransferase 9 isoform 2

    See identical proteins and their annotated locations for NP_001291387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC093835, AK096703, BC004337, DB077123
    UniProtKB/Swiss-Prot
    Q6P2P2
    Conserved Domains (1) summary
    cl17173
    Location:35190
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001350141.1NP_001337070.1  protein arginine N-methyltransferase 9 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC093835
  3. NM_001350142.1NP_001337071.1  protein arginine N-methyltransferase 9 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093835
    Conserved Domains (1) summary
    cl17173
    Location:35190
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. NM_001350143.1NP_001337072.1  protein arginine N-methyltransferase 9 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC093835
  5. NM_001350144.1NP_001337073.1  protein arginine N-methyltransferase 9 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC093835
  6. NM_138364.4NP_612373.2  protein arginine N-methyltransferase 9 isoform 1

    See identical proteins and their annotated locations for NP_612373.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC093835, BC004337, BC064403, DB077123
    Consensus CDS
    CCDS3771.1
    UniProtKB/Swiss-Prot
    Q6P2P2
    Related
    ENSP00000314396.6, ENST00000322396.7
    Conserved Domains (3) summary
    COG0457
    Location:39144
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:6895
    TPR; TPR repeat [structural motif]
    cl17173
    Location:148303
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    147635650..147684230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008823.2XP_016864312.1  protein arginine N-methyltransferase 9 isoform X1

  2. XM_017008825.1XP_016864314.1  protein arginine N-methyltransferase 9 isoform X1

  3. XM_017008826.1XP_016864315.1  protein arginine N-methyltransferase 9 isoform X1

  4. XM_017008824.2XP_016864313.1  protein arginine N-methyltransferase 9 isoform X1

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