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ANGEL2 angel homolog 2 [ Homo sapiens (human) ]

Gene ID: 90806, updated on 1-Jun-2020

Summary

Official Symbol
ANGEL2provided by HGNC
Official Full Name
angel homolog 2provided by HGNC
Primary source
HGNC:HGNC:30534
See related
Ensembl:ENSG00000174606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ccr4d; KIAA0759L
Expression
Ubiquitous expression in brain (RPKM 5.6), lymph node (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See ANGEL2 in Genome Data Viewer
Location:
1q32.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (212992182..213015875, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (213165524..213189168, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene FLVCR heme transporter 1 Neighboring gene Sharpr-MPRA regulatory region 306 Neighboring gene vasohibin 2 Neighboring gene CRISPRi-validated cis-regulatory element chr1.11646 Neighboring gene ribosomal protein S6 kinase C1 Neighboring gene VISTA enhancer hs1324

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12793

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-UTR-mediated mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300753.1NP_001287682.1  protein angel homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001287682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AF510741, AI658922, AK022855, AK294479, BX103687, DC395916
    UniProtKB/Swiss-Prot
    Q5VTE6
    UniProtKB/TrEMBL
    B7Z297
    Conserved Domains (1) summary
    cl00490
    Location:43416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  2. NM_001300755.1NP_001287684.1  protein angel homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001287684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AF510741, AI658922, AK022855, AK299208, BX103687, DA718585
    UniProtKB/Swiss-Prot
    Q5VTE6
    UniProtKB/TrEMBL
    B7Z5N3
    Conserved Domains (1) summary
    cl00490
    Location:43416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  3. NM_001300757.1NP_001287686.1  protein angel homolog 2 isoform c

    See identical proteins and their annotated locations for NP_001287686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AF510741, AI658922, AK022855, BX103687, DC395916
    Consensus CDS
    CCDS73027.1
    UniProtKB/Swiss-Prot
    Q5VTE6
    Related
    ENSP00000438141.2, ENST00000535388.2
    Conserved Domains (1) summary
    cl00490
    Location:1373
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  4. NM_001300758.1NP_001287687.1  protein angel homolog 2 isoform c

    See identical proteins and their annotated locations for NP_001287687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AI658922, AK022855, AL079275, BC047469, BX103687, DC395916
    Consensus CDS
    CCDS73027.1
    UniProtKB/Swiss-Prot
    Q5VTE6
    Related
    ENSP00000353696.2, ENST00000360506.6
    Conserved Domains (1) summary
    cl00490
    Location:1373
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  5. NM_144567.5NP_653168.2  protein angel homolog 2 isoform a

    See identical proteins and their annotated locations for NP_653168.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF510741, AI658922, AK022855, AL079275, BC016966, BC047469, BX103687, DC395916
    Consensus CDS
    CCDS1512.1
    UniProtKB/Swiss-Prot
    Q5VTE6
    UniProtKB/TrEMBL
    Q96AL9
    Related
    ENSP00000355929.3, ENST00000366962.8
    Conserved Domains (1) summary
    cl00490
    Location:169542
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RNA

  1. NR_125333.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF510741, AI658922, AK022855, AK299365, BX103687, DC395916

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    212992182..213015875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002775.1XP_016858264.1  protein angel homolog 2 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:43416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  2. XM_017002774.1XP_016858263.1  protein angel homolog 2 isoform X1

    Conserved Domains (1) summary
    cl00490
    Location:147520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  3. XM_017002778.1XP_016858267.1  protein angel homolog 2 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:43416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  4. XM_005273344.1XP_005273401.1  protein angel homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005273401.1

    Conserved Domains (1) summary
    cl00490
    Location:147520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  5. XM_017002776.1XP_016858265.1  protein angel homolog 2 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:43416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  6. XM_005273347.3XP_005273404.1  protein angel homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_005273404.1

    Conserved Domains (1) summary
    cl00490
    Location:90463
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  7. XM_005273345.1XP_005273402.1  protein angel homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005273402.1

    Conserved Domains (1) summary
    cl00490
    Location:147520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  8. XM_017002777.1XP_016858266.1  protein angel homolog 2 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:43416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  9. XM_005273346.2XP_005273403.1  protein angel homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005273403.1

    Conserved Domains (1) summary
    cl00490
    Location:147520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RNA

  1. XR_001737530.1 RNA Sequence

  2. XR_001737531.1 RNA Sequence

  3. XR_001737529.2 RNA Sequence

  4. XR_001737528.1 RNA Sequence

  5. XR_001737532.1 RNA Sequence

  6. XR_247045.3 RNA Sequence

  7. XR_001737527.1 RNA Sequence

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