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ANGPTL1 angiopoietin like 1 [ Homo sapiens (human) ]

Gene ID: 9068, updated on 22-Jan-2020

Summary

Official Symbol
ANGPTL1provided by HGNC
Official Full Name
angiopoietin like 1provided by HGNC
Primary source
HGNC:HGNC:489
See related
Ensembl:ENSG00000116194 MIM:603874
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANG3; ARP1; AngY; ANGPT3; UNQ162; dJ595C2.2
Summary
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary (RPKM 20.0), placenta (RPKM 16.0) and 21 other tissues See more
Orthologs

Genomic context

See ANGPTL1 in Genome Data Viewer
Location:
1q25.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (178849535..178871077, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (178818670..178840215, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2 Neighboring gene Ral GEF with PH domain and SH3 binding motif 2 Neighboring gene PTPN2 pseudogene 1 Neighboring gene uncharacterized LOC102724754 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10033

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of angiopoietin-like 1 (ANGPTL1) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0351

Gene Ontology Provided by GOA

Function Evidence Code Pubs
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
angiopoietin-related protein 1
Names
ANG-3
angioarrestin
angiopoietin 3
angiopoietin Y1
angiopoietin-like protein 1
dJ595C2.2 (angiopoietin Y1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376763.1NP_001363692.1  angiopoietin-related protein 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL355520
    Related
    ENSP00000356601.1, ENST00000367629.1
  2. NM_004673.4NP_004664.1  angiopoietin-related protein 1 precursor

    See identical proteins and their annotated locations for NP_004664.1

    Status: REVIEWED

    Source sequence(s)
    AF086266, AY358278, BC050640, BM710120, BX499002
    Consensus CDS
    CCDS1327.1
    UniProtKB/Swiss-Prot
    O95841
    UniProtKB/TrEMBL
    A0A024R908
    Related
    ENSP00000234816.2, ENST00000234816.7
    Conserved Domains (2) summary
    cd00087
    Location:275490
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl02720
    Location:74138
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    178849535..178871077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_241102.5 RNA Sequence

  2. XR_002957991.1 RNA Sequence

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