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SYT7 synaptotagmin 7 [ Homo sapiens (human) ]

Gene ID: 9066, updated on 23-Nov-2023

Summary

Official Symbol
SYT7provided by HGNC
Official Full Name
synaptotagmin 7provided by HGNC
Primary source
HGNC:HGNC:11514
See related
Ensembl:ENSG00000011347 MIM:604146; AllianceGenome:HGNC:11514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPCA7; IPCA-7; SYTVII; PCANAP7; SYT-VII
Summary
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in brain (RPKM 15.4), prostate (RPKM 13.8) and 12 other tissues See more
Orthologs
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Genomic context

See SYT7 in Genome Data Viewer
Location:
11q12.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61513714..61588387, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61502594..61577283, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61281186..61348548, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61280313-61280926 Neighboring gene leucine rich repeat containing 10B Neighboring gene microRNA 4488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61297435-61297934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61301414-61302353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61302354-61303292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3396 Neighboring gene uncharacterized LOC105369331 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61354237-61354816 Neighboring gene uncharacterized LOC101927495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61355975-61356553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61366831-61367498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61368167-61368834 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61393636-61394198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61394199-61394759 Neighboring gene Sharpr-MPRA regulatory region 3465 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61396115-61397096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61406067-61406567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61406607-61407134

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC150517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-dependent phospholipid binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in calcium ion regulated lysosome exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion-regulated exocytosis of neurotransmitter ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phagosome-lysosome fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in plasma membrane repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of glucagon secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in short-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle recycling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle-mediated cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in dense core granule IEA
Inferred from Electronic Annotation
more info
 
located_in early phagosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synaptotagmin-7
Names
prostate cancer-associated protein 7
synaptotagmin VII

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252065.2NP_001238994.1  synaptotagmin-7 isoform 1

    See identical proteins and their annotated locations for NP_001238994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AP002754, AP003108, BC042495, BC125171, BE644642, BM675410, BQ447018
    Consensus CDS
    CCDS58139.1
    UniProtKB/Swiss-Prot
    O43581
    Related
    ENSP00000444201.1, ENST00000540677.5
    Conserved Domains (2) summary
    cd08386
    Location:210334
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:342477
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  2. NM_001300773.2NP_001287702.1  synaptotagmin-7 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in place of another alternate in-frame exon compared to variant 1. The resulting isoform (3) has an alternate 44 aa internal segment in place of an alternate 75 aa internal segment compared to isoform 1.
    Source sequence(s)
    AP002754, AP003108, BC042495, BC125170, BE644642, BQ447018, CA868518
    Consensus CDS
    CCDS73298.1
    UniProtKB/Swiss-Prot
    O43581
    Related
    ENSP00000444568.1, ENST00000542836.5
    Conserved Domains (2) summary
    cd08386
    Location:179303
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:311446
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  3. NM_001365809.2NP_001352738.1  synaptotagmin-7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AP002754, AP003108, AP003559
    Consensus CDS
    CCDS91487.1
    Related
    ENSP00000439694.1, ENST00000539008.6
    Conserved Domains (3) summary
    cd08386
    Location:418542
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:550685
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    PHA03307
    Location:143310
    PHA03307; transcriptional regulator ICP4; Provisional
  4. NM_001370210.1NP_001357139.1  synaptotagmin-7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AP003108, AP003559
    Conserved Domains (2) summary
    cd08386
    Location:231355
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cl14603
    Location:363466
    C2; C2 domain
  5. NM_001370211.1NP_001357140.1  synaptotagmin-7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP002754, AP003108, AP003559
    Conserved Domains (2) summary
    cd08386
    Location:135259
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cl14603
    Location:267370
    C2; C2 domain
  6. NM_001411007.1NP_001397936.1  synaptotagmin-7 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AP002754, AP003108, AP003559
    Consensus CDS
    CCDS91486.1
    Related
    ENSP00000437720.1, ENST00000535826.5
  7. NM_004200.4NP_004191.2  synaptotagmin-7 isoform 2

    See identical proteins and their annotated locations for NP_004191.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AP002754, AP003108, BC042495, BC125170, BE644642, BM675410, BQ447018
    Consensus CDS
    CCDS31577.1
    UniProtKB/Swiss-Prot
    F5GZC2, F5GZU9, F5H126, F5H1N2, F5H6C1, O43581, Q08AH6
    Related
    ENSP00000263846.4, ENST00000263846.8
    Conserved Domains (2) summary
    cd08386
    Location:135259
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:267402
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    61513714..61588387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545343.3XP_011543645.1  synaptotagmin-7 isoform X12

    Conserved Domains (2) summary
    cd08386
    Location:141265
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:273408
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  2. XM_011545340.3XP_011543642.1  synaptotagmin-7 isoform X8

    Conserved Domains (2) summary
    cd08386
    Location:216340
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:348483
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  3. XM_011545337.3XP_011543639.1  synaptotagmin-7 isoform X3

    Conserved Domains (2) summary
    cd08386
    Location:380504
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:512647
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  4. XM_011545341.3XP_011543643.1  synaptotagmin-7 isoform X9

    Conserved Domains (2) summary
    cd08386
    Location:185309
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:317452
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  5. XM_011545338.3XP_011543640.1  synaptotagmin-7 isoform X5

    Conserved Domains (2) summary
    cd08386
    Location:349473
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:481616
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  6. XM_011545339.3XP_011543641.1  synaptotagmin-7 isoform X7

    Conserved Domains (2) summary
    cd08386
    Location:260384
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:392527
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  7. XM_011545336.3XP_011543638.1  synaptotagmin-7 isoform X2

    Conserved Domains (2) summary
    cd08386
    Location:383507
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:515650
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  8. XM_011545335.3XP_011543637.1  synaptotagmin-7 isoform X1

    Conserved Domains (2) summary
    cd08386
    Location:424548
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:556691
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  9. XM_005274384.3XP_005274441.1  synaptotagmin-7 isoform X4

    Conserved Domains (3) summary
    cd08386
    Location:374498
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:506641
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    PHA03307
    Location:99266
    PHA03307; transcriptional regulator ICP4; Provisional
  10. XM_005274385.5XP_005274442.1  synaptotagmin-7 isoform X6

    UniProtKB/Swiss-Prot
    O43581
    Related
    ENSP00000444019.1, ENST00000542670.5
    Conserved Domains (2) summary
    cd08386
    Location:343467
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:475610
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  11. XM_005274387.5XP_005274444.1  synaptotagmin-7 isoform X10

    Conserved Domains (2) summary
    cd08386
    Location:181305
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:313448
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  12. XM_011545342.3XP_011543644.1  synaptotagmin-7 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    61502594..61577283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370458.1XP_054226433.1  synaptotagmin-7 isoform X9

  2. XM_054370461.1XP_054226436.1  synaptotagmin-7 isoform X12

  3. XM_054370456.1XP_054226431.1  synaptotagmin-7 isoform X7

  4. XM_054370450.1XP_054226425.1  synaptotagmin-7 isoform X1

  5. XM_054370452.1XP_054226427.1  synaptotagmin-7 isoform X3

  6. XM_054370451.1XP_054226426.1  synaptotagmin-7 isoform X2

  7. XM_054370454.1XP_054226429.1  synaptotagmin-7 isoform X5

  8. XM_054370457.1XP_054226432.1  synaptotagmin-7 isoform X8

  9. XM_054370453.1XP_054226428.1  synaptotagmin-7 isoform X4

  10. XM_054370455.1XP_054226430.1  synaptotagmin-7 isoform X6

  11. XM_054370459.1XP_054226434.1  synaptotagmin-7 isoform X10

  12. XM_054370460.1XP_054226435.1  synaptotagmin-7 isoform X11