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ZNF486 zinc finger protein 486 [ Homo sapiens (human) ]

Gene ID: 90649, updated on 11-Jun-2021

Summary

Official Symbol
ZNF486provided by HGNC
Official Full Name
zinc finger protein 486provided by HGNC
Primary source
HGNC:HGNC:20807
See related
Ensembl:ENSG00000256229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRBO2
Expression
Broad expression in thyroid (RPKM 2.9), urinary bladder (RPKM 1.2) and 17 other tissues See more
Orthologs
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Genomic context

See ZNF486 in Genome Data Viewer
Location:
19p12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (20167214..20200488)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (20278023..20311297)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 90 Neighboring gene uncharacterized LOC105372310 Neighboring gene ribosomal protein S16 pseudogene 10 Neighboring gene BCL2 interacting protein 3 pseudogene 15 Neighboring gene BCL2 interacting protein 3 pseudogene 16 Neighboring gene zinc finger protein 107 pseudogene Neighboring gene uncharacterized LOC105372311 Neighboring gene BCL2 interacting protein 3 pseudogene 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2396

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 486
Names
KRAB box only protein 2
KRAB domain only 2
KRAB domain only protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052852.4NP_443084.2  zinc finger protein 486

    See identical proteins and their annotated locations for NP_443084.2

    Status: VALIDATED

    Source sequence(s)
    AC011447, BC027608
    Consensus CDS
    CCDS46029.1
    UniProtKB/Swiss-Prot
    Q96H40
    UniProtKB/TrEMBL
    Q4G180
    Related
    ENSP00000335042.7, ENST00000335117.9
    Conserved Domains (5) summary
    smart00349
    Location:1371
    KRAB; krueppel associated box
    COG5048
    Location:188463
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1552
    KRAB; KRAB box
    pfam13465
    Location:337361
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    20167214..20200488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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