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MAP3K6 mitogen-activated protein kinase kinase kinase 6 [ Homo sapiens (human) ]

Gene ID: 9064, updated on 1-Jun-2020

Summary

Official Symbol
MAP3K6provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 6provided by HGNC
Primary source
HGNC:HGNC:6858
See related
Ensembl:ENSG00000142733 MIM:604468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASK2; MEKK6; MAPKKK6
Summary
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Broad expression in skin (RPKM 18.7), fat (RPKM 11.6) and 21 other tissues See more
Orthologs

Genomic context

See MAP3K6 in Genome Data Viewer
Location:
1p36.11
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (27355179..27368037, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27681670..27693558, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 222 Neighboring gene actin gamma 1 pseudogene 20 Neighboring gene RNA, U6 small nuclear 48, pseudogene Neighboring gene synaptotagmin like 1 Neighboring gene ficolin 3 Neighboring gene CD164 molecule like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20114, MGC125653

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of JUN kinase activity TAS
Traceable Author Statement
more info
PubMed 
activation of MAPKK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 6
Names
apoptosis signal-regulating kinase 2
NP_001284538.1
NP_004663.3
XP_016858260.1
XP_016858261.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051309.1 RefSeqGene

    Range
    6077..17854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297609.2NP_001284538.1  mitogen-activated protein kinase kinase kinase 6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB208805, AI658745, AW771625, FO393419
    Consensus CDS
    CCDS72738.1
    UniProtKB/Swiss-Prot
    O95382
    Related
    ENSP00000363152.2, ENST00000374040.7
    Conserved Domains (3) summary
    smart00220
    Location:645898
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:631898
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:129498
    DUF4071; Domain of unknown function (DUF4071)
  2. NM_004672.5NP_004663.3  mitogen-activated protein kinase kinase kinase 6 isoform 1

    See identical proteins and their annotated locations for NP_004663.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB167411, AF100318, AW771625, FO393419
    Consensus CDS
    CCDS299.1
    UniProtKB/Swiss-Prot
    O95382
    Related
    ENSP00000350195.2, ENST00000357582.3
    Conserved Domains (3) summary
    smart00220
    Location:653906
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:639906
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:129506
    DUF4071; Domain of unknown function (DUF4071)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    27355179..27368037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002771.1XP_016858260.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

    Related
    ENST00000493901.6
  2. XM_017002772.1XP_016858261.1  mitogen-activated protein kinase kinase kinase 6 isoform X2

RNA

  1. XR_946795.3 RNA Sequence

  2. XR_946794.3 RNA Sequence

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