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PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [ Homo sapiens (human) ]

Gene ID: 9061, updated on 9-Dec-2018

Summary

Official Symbol
PAPSS1provided by HGNC
Official Full Name
3'-phosphoadenosine 5'-phosphosulfate synthase 1provided by HGNC
Primary source
HGNC:HGNC:8603
See related
Ensembl:ENSG00000138801 MIM:603262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SK1; PAPSS; ATPSK1
Summary
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in endometrium (RPKM 32.6), brain (RPKM 30.3) and 25 other tissues See more
Orthologs

Genomic context

See PAPSS1 in Genome Data Viewer
Location:
4q25
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (107613666..107720263, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (108534822..108641419, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 551, pseudogene Neighboring gene uncharacterized LOC105377358 Neighboring gene uncharacterized LOC105377357 Neighboring gene uncharacterized LOC101929595 Neighboring gene sphingomyelin synthase 2 Neighboring gene RNA, U6 small nuclear 733, pseudogene Neighboring gene uncharacterized LOC107986298 Neighboring gene uncharacterized LOC107986299 Neighboring gene cytochrome P450 family 2 subfamily U member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
NHGRI GWA Catalog

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Cytosolic sulfonation of small molecules, organism-specific biosystem (from REACTOME)
    Cytosolic sulfonation of small molecules, organism-specific biosystemTwo groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfona...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Metabolism of ingested H2SeO4 and H2SeO3 into H2Se, organism-specific biosystem (from REACTOME)
    Metabolism of ingested H2SeO4 and H2SeO3 into H2Se, organism-specific biosystemIngested selenic acid (H2SeO4) and selenite (SeO3(2-)) are reduced to hydrogen selenide (H2Se) through a combination of actions involving bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1...
  • Oncogenic MAPK signaling, organism-specific biosystem (from REACTOME)
    Oncogenic MAPK signaling, organism-specific biosystemThe importance of the RAS/RAF/MAPK cascade in regulating cellular proliferation, differentiation and survival is highlighted by the fact that components of the pathway are mutated with high frequency...
  • Phase II conjugation, organism-specific biosystem (from REACTOME)
    Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
  • Purine metabolism, organism-specific biosystem (from KEGG)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, conserved biosystem (from KEGG)
    Purine metabolism, conserved biosystem
    Purine metabolism
  • Selenoamino acid metabolism, organism-specific biosystem (from REACTOME)
    Selenoamino acid metabolism, organism-specific biosystemSelenium (Se) is a trace element essential for the normal function of the body. Selenoamino acids are defined as those amino acids where selenium has been substituted for sulphur. Selenium and sulp...
  • Selenocompound metabolism, organism-specific biosystem (from KEGG)
    Selenocompound metabolism, organism-specific biosystem
    Selenocompound metabolism
  • Selenocompound metabolism, conserved biosystem (from KEGG)
    Selenocompound metabolism, conserved biosystem
    Selenocompound metabolism
  • Signaling by BRAF and RAF fusions, organism-specific biosystem (from REACTOME)
    Signaling by BRAF and RAF fusions, organism-specific biosystemIn addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et ...
  • Sulfation Biotransformation Reaction, organism-specific biosystem (from WikiPathways)
    Sulfation Biotransformation Reaction, organism-specific biosystemMetabolism of xenobiotic compounds consists of phase I and a phase II biotransformation reactions, being compound modification and conjugation reactions respectively. In phase I biotransformation, th...
  • Sulfur metabolism, organism-specific biosystem (from KEGG)
    Sulfur metabolism, organism-specific biosystemSulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in...
  • Sulfur metabolism, conserved biosystem (from KEGG)
    Sulfur metabolism, conserved biosystemSulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in...
  • Transport and synthesis of PAPS, organism-specific biosystem (from REACTOME)
    Transport and synthesis of PAPS, organism-specific biosystemPAPS (3'-phosphoadenosine-5'-phosphosulfate), which functions as a sulfate donor in the cell, is synthesized from sulfate and two molecules of ATP in a two-step process (Robbins & Lipmann 1958) catal...
  • sulfate activation for sulfonation, organism-specific biosystem (from BIOCYC)
    sulfate activation for sulfonation, organism-specific biosystemGeneral Background The sulfonation of biological compounds (sulfoconjugation) is a fundamental metabolic process, in which a sulfate group is added to an oxygen moiety to form a sulfate ester bond. ...
  • sulfate activation for sulfonation, conserved biosystem (from BIOCYC)
    sulfate activation for sulfonation, conserved biosystemGeneral Background The sulfonation of biological compounds (sulfoconjugation) is a fundamental metabolic process, in which a sulfate group is added to an oxygen moiety to form a sulfate ester bond. ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
adenylylsulfate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylylsulfate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylylsulfate kinase activity TAS
Traceable Author Statement
more info
 
nucleotidyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
sulfate adenylyltransferase (ATP) activity IDA
Inferred from Direct Assay
more info
PubMed 
sulfate adenylyltransferase (ATP) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
sulfate adenylyltransferase (ATP) activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process TAS
Traceable Author Statement
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
sulfate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate assimilation IDA
Inferred from Direct Assay
more info
PubMed 
sulfate assimilation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Names
3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1
PAPS synthase 1
PAPSS 1
SK 1
adenylyl-sulfate kinase
sulfate adenylyltransferase
sulfurylase kinase 1
NP_005434.4
XP_011530702.1
XP_011530703.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005443.5NP_005434.4  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

    See identical proteins and their annotated locations for NP_005434.4

    Status: VALIDATED

    Source sequence(s)
    AU132232, BC011392, BQ437924
    Consensus CDS
    CCDS3676.1
    UniProtKB/Swiss-Prot
    O43252
    Related
    ENSP00000265174.4, ENST00000265174.4
    Conserved Domains (2) summary
    cd00517
    Location:254617
    ATPS; ATP-sulfurylase
    pfam01583
    Location:51205
    APS_kinase; Adenylylsulphate kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    107613666..107720263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532401.1XP_011530703.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

    See identical proteins and their annotated locations for XP_011530703.1

    UniProtKB/Swiss-Prot
    O43252
    Conserved Domains (3) summary
    cd00517
    Location:233596
    ATPS; ATP-sulfurylase
    TIGR00339
    Location:212595
    sopT; ATP sulphurylase
    pfam01583
    Location:30184
    APS_kinase; Adenylylsulphate kinase
  2. XM_011532400.2XP_011530702.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

    See identical proteins and their annotated locations for XP_011530702.1

    UniProtKB/Swiss-Prot
    O43252
    Conserved Domains (3) summary
    cd00517
    Location:233596
    ATPS; ATP-sulfurylase
    TIGR00339
    Location:212595
    sopT; ATP sulphurylase
    pfam01583
    Location:30184
    APS_kinase; Adenylylsulphate kinase
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