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PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [ Homo sapiens (human) ]

Gene ID: 9061, updated on 21-Dec-2019

Summary

Official Symbol
PAPSS1provided by HGNC
Official Full Name
3'-phosphoadenosine 5'-phosphosulfate synthase 1provided by HGNC
Primary source
HGNC:HGNC:8603
See related
Ensembl:ENSG00000138801 MIM:603262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SK1; PAPSS; ATPSK1
Summary
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in endometrium (RPKM 32.6), brain (RPKM 30.3) and 25 other tissues See more
Orthologs

Genomic context

See PAPSS1 in Genome Data Viewer
Location:
4q25
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (107613666..107720234, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (108534822..108641419, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 551, pseudogene Neighboring gene uncharacterized LOC105377358 Neighboring gene uncharacterized LOC105377357 Neighboring gene uncharacterized LOC101929595 Neighboring gene sphingomyelin synthase 2 Neighboring gene RNA, U6 small nuclear 733, pseudogene Neighboring gene uncharacterized LOC107986298 Neighboring gene uncharacterized LOC107986299 Neighboring gene cytochrome P450 family 2 subfamily U member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
adenylylsulfate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotidyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
sulfate adenylyltransferase (ATP) activity IDA
Inferred from Direct Assay
more info
PubMed 
sulfate adenylyltransferase (ATP) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process TAS
Traceable Author Statement
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
sulfate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate assimilation IDA
Inferred from Direct Assay
more info
PubMed 
sulfate assimilation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Names
3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1
PAPS synthase 1
PAPSS 1
SK 1
adenylyl-sulfate kinase
sulfate adenylyltransferase
sulfurylase kinase 1
NP_005434.4
XP_011530702.1
XP_011530703.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005443.5NP_005434.4  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

    See identical proteins and their annotated locations for NP_005434.4

    Status: VALIDATED

    Source sequence(s)
    AU132232, BC011392, BQ437924
    Consensus CDS
    CCDS3676.1
    UniProtKB/Swiss-Prot
    O43252
    Related
    ENSP00000265174.4, ENST00000265174.5
    Conserved Domains (2) summary
    cd00517
    Location:254617
    ATPS; ATP-sulfurylase
    pfam01583
    Location:51205
    APS_kinase; Adenylylsulphate kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    107613666..107720234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532401.1XP_011530703.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

    See identical proteins and their annotated locations for XP_011530703.1

    UniProtKB/Swiss-Prot
    O43252
    Conserved Domains (3) summary
    cd00517
    Location:233596
    ATPS; ATP-sulfurylase
    TIGR00339
    Location:212595
    sopT; ATP sulphurylase
    pfam01583
    Location:30184
    APS_kinase; Adenylylsulphate kinase
  2. XM_011532400.2XP_011530702.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

    See identical proteins and their annotated locations for XP_011530702.1

    UniProtKB/Swiss-Prot
    O43252
    Conserved Domains (3) summary
    cd00517
    Location:233596
    ATPS; ATP-sulfurylase
    TIGR00339
    Location:212595
    sopT; ATP sulphurylase
    pfam01583
    Location:30184
    APS_kinase; Adenylylsulphate kinase
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