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CCDC74A coiled-coil domain containing 74A [ Homo sapiens (human) ]

Gene ID: 90557, updated on 23-Nov-2021

Summary

Official Symbol
CCDC74Aprovided by HGNC
Official Full Name
coiled-coil domain containing 74Aprovided by HGNC
Primary source
HGNC:HGNC:25197
See related
Ensembl:ENSG00000163040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 20.6), adrenal (RPKM 5.0) and 10 other tissues See more
Orthologs
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Genomic context

See CCDC74A in Genome Data Viewer
Location:
2q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (131522621..131533666)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (132285461..132291239)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene mitotic spindle organizing protein 2A Neighboring gene microRNA 4784 Neighboring gene sphingomyelin phosphodiesterase 4B, pseudogene Neighboring gene mediator complex subunit 15 pseudogene 4 Neighboring gene POTE ankyrin domain family member K, pseudogene Neighboring gene RNA, U6 small nuclear 617, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
coiled-coil domain-containing protein 74A
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258304.3NP_001245233.1  coiled-coil domain-containing protein 74A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice sites in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB299086, BC016861, CV023784, DA375407
    Conserved Domains (2) summary
    pfam14916
    Location:47142
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:257372
    CCDC74_C; Coiled coil protein 74, C terminal
  2. NM_001258305.3NP_001245234.1  coiled-coil domain-containing protein 74A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB299087, BC016861, CV023784, DA375407
    Consensus CDS
    CCDS74578.1
    UniProtKB/TrEMBL
    F5GZA4
    Related
    ENSP00000444610.2, ENST00000467992.6
    Conserved Domains (1) summary
    pfam14916
    Location:47100
    CCDC92; Coiled-coil domain of unknown function
  3. NM_001258306.3NP_001245235.1  coiled-coil domain-containing protein 74A isoform 4

    See identical proteins and their annotated locations for NP_001245235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    BC016861, BC063387, DA375407
    Consensus CDS
    CCDS58732.1
    UniProtKB/Swiss-Prot
    Q96AQ1
    Related
    ENSP00000387009.3, ENST00000409856.8
    Conserved Domains (2) summary
    pfam14916
    Location:47100
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:197309
    CCDC74_C; Coiled coil protein 74, C terminal
  4. NM_001349041.2NP_001335970.1  coiled-coil domain-containing protein 74A isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC093838, BC016861
    Conserved Domains (1) summary
    pfam14916
    Location:47100
    CCDC92; Coiled-coil domain of unknown function
  5. NM_001349042.2NP_001335971.1  coiled-coil domain-containing protein 74A isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 5' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (6) is longer than isoform 1.
    Source sequence(s)
    AC093838, BC016861
    Conserved Domains (2) summary
    pfam14916
    Location:47142
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:305417
    CCDC74_C; Coiled coil protein 74, C terminal
  6. NM_001349043.2NP_001335972.1  coiled-coil domain-containing protein 74A isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses two alternate splice sites in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.
    Source sequence(s)
    AC093838, BC016861
    Conserved Domains (2) summary
    pfam14916
    Location:4783
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:239351
    CCDC74_C; Coiled coil protein 74, C terminal
  7. NM_001349044.2NP_001335973.1  coiled-coil domain-containing protein 74A isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses three alternate splice sites in the coding region, one of which results in a frameshift, compared to variant 1. The encoded isoform (8) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC093838, BC016861
    Conserved Domains (1) summary
    pfam14916
    Location:47142
    CCDC92; Coiled-coil domain of unknown function
  8. NM_001349045.2NP_001335974.1  coiled-coil domain-containing protein 74A isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The encoded isoform (9) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC093838, BC016861
    Conserved Domains (1) summary
    pfam14916
    Location:4783
    CCDC92; Coiled-coil domain of unknown function
  9. NM_001349046.2NP_001335975.1  coiled-coil domain-containing protein 74A isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The encoded isoform (10) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC093838, BC016861
    Conserved Domains (1) summary
    pfam14916
    Location:47100
    CCDC92; Coiled-coil domain of unknown function
  10. NM_001349047.2NP_001335976.1  coiled-coil domain-containing protein 74A isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) uses two alternate splice sites in the coding region, one of which results in a frameshift, compared to variant 1. The encoded isoform (11) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC093838, BC016861
    Conserved Domains (2) summary
    pfam14916
    Location:47100
    CCDC92; Coiled-coil domain of unknown function
    cl26585
    Location:53153
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
  11. NM_138770.4NP_620125.1  coiled-coil domain-containing protein 74A isoform 1

    See identical proteins and their annotated locations for NP_620125.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC016861, DA375407
    Consensus CDS
    CCDS2167.1
    UniProtKB/Swiss-Prot
    Q96AQ1
    Related
    ENSP00000295171.6, ENST00000295171.10
    Conserved Domains (2) summary
    pfam14916
    Location:47100
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:263375
    CCDC74_C; Coiled coil protein 74, C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    131522621..131533666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005241.1XP_016860730.1  coiled-coil domain-containing protein 74A isoform X8

  2. XM_017005244.1XP_016860733.1  coiled-coil domain-containing protein 74A isoform X9

  3. XM_017005235.1XP_016860724.1  coiled-coil domain-containing protein 74A isoform X3

  4. XM_017005239.1XP_016860728.1  coiled-coil domain-containing protein 74A isoform X7

  5. XM_017005238.1XP_016860727.1  coiled-coil domain-containing protein 74A isoform X6

  6. XM_017005237.1XP_016860726.1  coiled-coil domain-containing protein 74A isoform X5

  7. XM_017005234.2XP_016860723.1  coiled-coil domain-containing protein 74A isoform X2

  8. XM_017005236.1XP_016860725.1  coiled-coil domain-containing protein 74A isoform X4

  9. XM_017005245.1XP_016860734.1  coiled-coil domain-containing protein 74A isoform X10

  10. XM_005263837.1XP_005263894.1  coiled-coil domain-containing protein 74A isoform X11

    Conserved Domains (1) summary
    pfam14917
    Location:95207
    CCDC74_C; Coiled coil protein 74, C terminal
  11. XM_005263836.4XP_005263893.1  coiled-coil domain-containing protein 74A isoform X1

    Conserved Domains (1) summary
    pfam14917
    Location:365477
    CCDC74_C; Coiled coil protein 74, C terminal

RNA

  1. XR_002959362.1 RNA Sequence

  2. XR_001739028.1 RNA Sequence

  3. XR_002959361.1 RNA Sequence

  4. XR_001739029.1 RNA Sequence

  5. XR_923059.2 RNA Sequence

  6. XR_923060.2 RNA Sequence

  7. XR_427121.3 RNA Sequence

  8. XR_002959360.1 RNA Sequence

  9. XR_002959359.1 RNA Sequence

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