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PRC1 protein regulator of cytokinesis 1 [ Homo sapiens (human) ]

Gene ID: 9055, updated on 26-Sep-2021

Summary

Official Symbol
PRC1provided by HGNC
Official Full Name
protein regulator of cytokinesis 1provided by HGNC
Primary source
HGNC:HGNC:9341
See related
Ensembl:ENSG00000198901 MIM:603484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASE1
Summary
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Expression
Broad expression in bone marrow (RPKM 31.0), testis (RPKM 24.4) and 18 other tissues See more
Orthologs
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Genomic context

See PRC1 in Genome Data Viewer
Location:
15q26.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (90966038..90994576, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91509270..91537765, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone A Neighboring gene RCCD1 and UNC45A antisense RNA 1 Neighboring gene RCC1 domain containing 1 Neighboring gene PRC1 antisense RNA 1 Neighboring gene VPS33B late endosome and lysosome associated Neighboring gene uncharacterized LOC105370970 Neighboring gene VPS33B divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.
GeneReviews: Not available
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
GeneReviews: Not available
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1671, MGC3669

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle elongation TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in contractile ring IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle microtubule TAS
Traceable Author Statement
more info
PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein regulator of cytokinesis 1
Names
anaphase spindle elongation 1 homolog
protein regulating cytokinesis 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050647.1 RefSeqGene

    Range
    5001..33614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267580.2NP_001254509.2  protein regulator of cytokinesis 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses and alternate splice site and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC068831
    Consensus CDS
    CCDS45353.2
    Related
    ENSP00000409549.2, ENST00000442656.6
    Conserved Domains (1) summary
    pfam03999
    Location:22508
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
  2. NM_003981.4NP_003972.2  protein regulator of cytokinesis 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC068831
    Consensus CDS
    CCDS32334.1
    Related
    ENSP00000377793.3, ENST00000394249.8
    Conserved Domains (1) summary
    pfam03999
    Location:37615
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
  3. NM_199413.3NP_955445.2  protein regulator of cytokinesis 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC068831
    Consensus CDS
    CCDS45352.1
    Related
    ENSP00000354679.5, ENST00000361188.9
    Conserved Domains (1) summary
    pfam03999
    Location:37601
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    90966038..90994576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522192.2XP_011520494.1  protein regulator of cytokinesis 1 isoform X13

    Conserved Domains (4) summary
    pfam03999
    Location:37494
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:306444
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    pfam13094
    Location:35180
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    cl00711
    Location:141304
    Glyco_hydro_77; 4-alpha-glucanotransferase
  2. XM_017022716.2XP_016878205.1  protein regulator of cytokinesis 1 isoform X12

  3. XM_017022713.2XP_016878202.1  protein regulator of cytokinesis 1 isoform X5

  4. XM_011522189.2XP_011520491.1  protein regulator of cytokinesis 1 isoform X3

    Conserved Domains (2) summary
    pfam03999
    Location:37564
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  5. XM_017022712.2XP_016878201.1  protein regulator of cytokinesis 1 isoform X4

  6. XM_006720760.2XP_006720823.1  protein regulator of cytokinesis 1 isoform X11

    Conserved Domains (3) summary
    pfam03999
    Location:37562
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413562
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  7. XM_006720759.2XP_006720822.1  protein regulator of cytokinesis 1 isoform X10

    See identical proteins and their annotated locations for XP_006720822.1

    Conserved Domains (3) summary
    pfam03999
    Location:37549
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413560
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  8. XM_011522187.2XP_011520489.1  protein regulator of cytokinesis 1 isoform X1

    Conserved Domains (3) summary
    pfam03999
    Location:37601
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413551
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  9. XM_017022715.2XP_016878204.1  protein regulator of cytokinesis 1 isoform X7

  10. XM_017022717.1XP_016878206.1  protein regulator of cytokinesis 1 isoform X14

  11. XM_005254987.3XP_005255044.1  protein regulator of cytokinesis 1 isoform X8

    Conserved Domains (3) summary
    pfam03999
    Location:37560
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413551
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  12. XM_011522191.3XP_011520493.1  protein regulator of cytokinesis 1 isoform X10

    See identical proteins and their annotated locations for XP_011520493.1

    Conserved Domains (3) summary
    pfam03999
    Location:37549
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413560
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  13. XM_011522188.3XP_011520490.1  protein regulator of cytokinesis 1 isoform X2

    Conserved Domains (3) summary
    pfam03999
    Location:37583
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413551
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  14. XM_011522190.3XP_011520492.1  protein regulator of cytokinesis 1 isoform X9

    Conserved Domains (4) summary
    pfam03999
    Location:37544
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:356494
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    pfam13094
    Location:35194
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    cl00711
    Location:203354
    Glyco_hydro_77; 4-alpha-glucanotransferase
  15. XM_017022714.2XP_016878203.1  protein regulator of cytokinesis 1 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199414.1: Suppressed sequence

    Description
    NM_199414.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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