U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

STPG1 sperm tail PG-rich repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 90529, updated on 5-Aug-2022

Summary

Official Symbol
STPG1provided by HGNC
Official Full Name
sperm tail PG-rich repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:28070
See related
Ensembl:ENSG00000001460 MIM:615826; AllianceGenome:HGNC:28070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAPO2; C1orf201
Summary
Involved in positive regulation of apoptotic process and positive regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 15.3), brain (RPKM 3.3) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See STPG1 in Genome Data Viewer
Location:
1p36.11
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (24356999..24415044, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (24195358..24253417, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24683489..24741534, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 530 Neighboring gene Sharpr-MPRA regulatory region 347 Neighboring gene GRHL3 antisense RNA 1 Neighboring gene grainyhead like transcription factor 3 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:24691307-24692506 Neighboring gene NIPA like domain containing 3 Neighboring gene RCAN3 antisense RNA Neighboring gene RCAN family member 3 Neighboring gene Sharpr-MPRA regulatory region 2491 Neighboring gene NCMAP divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33340

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
O(6)-methylguanine-induced apoptosis 2
Names
O6-methylguanine-induced apoptosis 2
UPF0490 protein C1orf201
sperm-tail PG-rich repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199012.2NP_001185941.1  O(6)-methylguanine-induced apoptosis 2 isoform 1

    See identical proteins and their annotated locations for NP_001185941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    BC040212, BC063891
    Consensus CDS
    CCDS55581.1
    UniProtKB/Swiss-Prot
    Q5TH74, Q8WVQ3
    Related
    ENSP00000363530.1, ENST00000374409.5
  2. NM_001199013.2NP_001185942.1  O(6)-methylguanine-induced apoptosis 2 isoform 1

    See identical proteins and their annotated locations for NP_001185942.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
    Source sequence(s)
    AL031431, BC047705, BC063891, BI917854, BM922375
    Consensus CDS
    CCDS55581.1
    UniProtKB/Swiss-Prot
    Q5TH74, Q8WVQ3
    Related
    ENSP00000337461.4, ENST00000337248.9
  3. NM_001199014.2NP_001185943.1  O(6)-methylguanine-induced apoptosis 2 isoform 3

    See identical proteins and their annotated locations for NP_001185943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an additional exon in the 5' region, resulting in a downstream AUG start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL031431, BC035061, BC063891, BI917854
    UniProtKB/Swiss-Prot
    Q5TH74
  4. NM_178122.5NP_835223.1  O(6)-methylguanine-induced apoptosis 2 isoform 2

    See identical proteins and their annotated locations for NP_835223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon in the CDS compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL031431, BC047705, BI917854
    Consensus CDS
    CCDS253.1
    UniProtKB/Swiss-Prot
    Q5TH74
    Related
    ENSP00000003583.8, ENST00000003583.12

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    24356999..24415044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542403.3XP_011540705.2  O(6)-methylguanine-induced apoptosis 2 isoform X1

  2. XM_047433681.1XP_047289637.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    24195358..24253417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)