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LRRC46 leucine rich repeat containing 46 [ Homo sapiens (human) ]

Gene ID: 90506, updated on 23-Nov-2021

Summary

Official Symbol
LRRC46provided by HGNC
Official Full Name
leucine rich repeat containing 46provided by HGNC
Primary source
HGNC:HGNC:25047
See related
Ensembl:ENSG00000141294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 25.7) and lung (RPKM 4.4) See more
Orthologs
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Genomic context

See LRRC46 in Genome Data Viewer
Location:
17q21.32
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (47831670..47837719)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45909036..45915085)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 7 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene secernin 2 Neighboring gene Sp6 transcription factor Neighboring gene CRISPRi-validated cis-regulatory element chr17.3281 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3283

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23553, MGC16309

General protein information

Preferred Names
leucine-rich repeat-containing protein 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033413.4NP_219481.1  leucine-rich repeat-containing protein 46

    See identical proteins and their annotated locations for NP_219481.1

    Status: VALIDATED

    Source sequence(s)
    AC003665, BC010412, BM663857, DB024018
    Consensus CDS
    CCDS11518.1
    UniProtKB/Swiss-Prot
    Q96FV0
    Related
    ENSP00000269025.4, ENST00000269025.9
    Conserved Domains (3) summary
    COG4886
    Location:34142
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:4667
    LRR_1; leucine-rich repeat [structural motif]
    cl26677
    Location:240320
    PRK00708; sec-independent translocase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    47831670..47837719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257775.4XP_005257832.1  leucine-rich repeat-containing protein 46 isoform X1

    Conserved Domains (3) summary
    sd00031
    Location:5576
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:75115
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:54109
    LRR_8; Leucine rich repeat
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